The genomic sequence of the accidental pathogen Legionella pneumophila

Minchen Chien; Irina Morozova; Shundi Shi; Huitao Sheng; Jing Chen; Shawn M. Gomez; Gifty Asamani; Kendra Hill; John Nuara; Marc Feder; Justin Rineer; Joseph J. Greenberg; Valeria Steshenko; Samantha H. Park; Baohui Zhao; Elita Teplitskaya; John R. Edwards; Sergey Pampou; Anthi Georghiou; I. Chun Chou; William Iannuccilli; Michael E. Ulz; Dae H. Kim; Alex Geringer-Sameth; Curtis Goldsberry; Pavel Morozov; Stuart G. Fischer; Gil Segal; Xiaoyan Qu; Andrey Rzhetsky; Peisen Zhang; Eftihia Cayanis; Pieter J. De Jong; Jingyue Ju; Sergey Kalachikov; Howard A. Shuman; James J. Russo

doi:10.1126/science.1099776

The genomic sequence of the accidental pathogen Legionella pneumophila

Minchen Chien
, Irina Morozova
, Shundi Shi
, Huitao Sheng
, Jing Chen
, Shawn M. Gomez
, Gifty Asamani
, Kendra Hill
, John Nuara
, Marc Feder
, Justin Rineer
, Joseph J. Greenberg
, Valeria Steshenko
, Samantha H. Park
, Baohui Zhao
, Elita Teplitskaya
, John R. Edwards
, Sergey Pampou
, Anthi Georghiou
, I. Chun Chou

William Iannuccilli, Michael E. Ulz, Dae H. Kim, Alex Geringer-Sameth, Curtis Goldsberry, Pavel Morozov, Stuart G. Fischer, Gil Segal, Xiaoyan Qu, Andrey Rzhetsky, Peisen Zhang, Eftihia Cayanis, Pieter J. De Jong, Jingyue Ju, Sergey Kalachikov, Howard A. Shuman, James J. Russo^*

^*Corresponding author for this work

Biotechnology

Columbia University
Institut Pasteur Paris
Roswell Park Cancer Institute
UCSF Benioff Children's Hospital Oakland

Research output: Contribution to journal › Article › peer-review

420 Scopus citations

Abstract

We present the genomic sequence of Legionella pneumophila, the bacterial agent of Legionnaires' disease, a potentially fatal pneumonia acquired from aerosolized contaminated fresh water. The genome includes a 45-kilobase pair element that can exist in chromosomal and episomal forms, selective expansions of important gene families, genes for unexpected metabolic pathways, and previously unknown candidate virulence determinants. We highlight the genes that may account for Legionella's ability to survive in protozoa, mammalian macrophages, and inhospitable environmental niches and that may define new therapeutic targets.

Original language	English
Pages (from-to)	1966-1968
Number of pages	3
Journal	Science
Volume	305
Issue number	5692
DOIs	https://doi.org/10.1126/science.1099776
State	Published - 24 Sep 2004

Funding

Funders	Funder number
National Institute of Allergy and Infectious Diseases	R01AI023549

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1126/science.1099776

Cite this

Chien, M., Morozova, I., Shi, S., Sheng, H., Chen, J., Gomez, S. M., Asamani, G., Hill, K., Nuara, J., Feder, M., Rineer, J., Greenberg, J. J., Steshenko, V., Park, S. H., Zhao, B., Teplitskaya, E., Edwards, J. R., Pampou, S., Georghiou, A., ... Russo, J. J. (2004). The genomic sequence of the accidental pathogen Legionella pneumophila. Science, 305(5692), 1966-1968. https://doi.org/10.1126/science.1099776

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title = "The genomic sequence of the accidental pathogen Legionella pneumophila",

abstract = "We present the genomic sequence of Legionella pneumophila, the bacterial agent of Legionnaires' disease, a potentially fatal pneumonia acquired from aerosolized contaminated fresh water. The genome includes a 45-kilobase pair element that can exist in chromosomal and episomal forms, selective expansions of important gene families, genes for unexpected metabolic pathways, and previously unknown candidate virulence determinants. We highlight the genes that may account for Legionella's ability to survive in protozoa, mammalian macrophages, and inhospitable environmental niches and that may define new therapeutic targets.",

author = "Minchen Chien and Irina Morozova and Shundi Shi and Huitao Sheng and Jing Chen and Gomez, \{Shawn M.\} and Gifty Asamani and Kendra Hill and John Nuara and Marc Feder and Justin Rineer and Greenberg, \{Joseph J.\} and Valeria Steshenko and Park, \{Samantha H.\} and Baohui Zhao and Elita Teplitskaya and Edwards, \{John R.\} and Sergey Pampou and Anthi Georghiou and Chou, \{I. Chun\} and William Iannuccilli and Ulz, \{Michael E.\} and Kim, \{Dae H.\} and Alex Geringer-Sameth and Curtis Goldsberry and Pavel Morozov and Fischer, \{Stuart G.\} and Gil Segal and Xiaoyan Qu and Andrey Rzhetsky and Peisen Zhang and Eftihia Cayanis and \{De Jong\}, \{Pieter J.\} and Jingyue Ju and Sergey Kalachikov and Shuman, \{Howard A.\} and Russo, \{James J.\}",

year = "2004",

month = sep,

day = "24",

doi = "10.1126/science.1099776",

language = "אנגלית",

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Chien, M, Morozova, I, Shi, S, Sheng, H, Chen, J, Gomez, SM, Asamani, G, Hill, K, Nuara, J, Feder, M, Rineer, J, Greenberg, JJ, Steshenko, V, Park, SH, Zhao, B, Teplitskaya, E, Edwards, JR, Pampou, S, Georghiou, A, Chou, IC, Iannuccilli, W, Ulz, ME, Kim, DH, Geringer-Sameth, A, Goldsberry, C, Morozov, P, Fischer, SG, Segal, G, Qu, X, Rzhetsky, A, Zhang, P, Cayanis, E, De Jong, PJ, Ju, J, Kalachikov, S, Shuman, HA & Russo, JJ 2004, 'The genomic sequence of the accidental pathogen Legionella pneumophila', Science, vol. 305, no. 5692, pp. 1966-1968. https://doi.org/10.1126/science.1099776

TY - JOUR

T1 - The genomic sequence of the accidental pathogen Legionella pneumophila

AU - Chien, Minchen

AU - Morozova, Irina

AU - Shi, Shundi

AU - Sheng, Huitao

AU - Chen, Jing

AU - Gomez, Shawn M.

AU - Asamani, Gifty

AU - Hill, Kendra

AU - Nuara, John

AU - Feder, Marc

AU - Rineer, Justin

AU - Greenberg, Joseph J.

AU - Steshenko, Valeria

AU - Park, Samantha H.

AU - Zhao, Baohui

AU - Teplitskaya, Elita

AU - Edwards, John R.

AU - Pampou, Sergey

AU - Georghiou, Anthi

AU - Chou, I. Chun

AU - Iannuccilli, William

AU - Ulz, Michael E.

AU - Kim, Dae H.

AU - Geringer-Sameth, Alex

AU - Goldsberry, Curtis

AU - Morozov, Pavel

AU - Fischer, Stuart G.

AU - Segal, Gil

AU - Qu, Xiaoyan

AU - Rzhetsky, Andrey

AU - Zhang, Peisen

AU - Cayanis, Eftihia

AU - De Jong, Pieter J.

AU - Ju, Jingyue

AU - Kalachikov, Sergey

AU - Shuman, Howard A.

AU - Russo, James J.

PY - 2004/9/24

Y1 - 2004/9/24

N2 - We present the genomic sequence of Legionella pneumophila, the bacterial agent of Legionnaires' disease, a potentially fatal pneumonia acquired from aerosolized contaminated fresh water. The genome includes a 45-kilobase pair element that can exist in chromosomal and episomal forms, selective expansions of important gene families, genes for unexpected metabolic pathways, and previously unknown candidate virulence determinants. We highlight the genes that may account for Legionella's ability to survive in protozoa, mammalian macrophages, and inhospitable environmental niches and that may define new therapeutic targets.

AB - We present the genomic sequence of Legionella pneumophila, the bacterial agent of Legionnaires' disease, a potentially fatal pneumonia acquired from aerosolized contaminated fresh water. The genome includes a 45-kilobase pair element that can exist in chromosomal and episomal forms, selective expansions of important gene families, genes for unexpected metabolic pathways, and previously unknown candidate virulence determinants. We highlight the genes that may account for Legionella's ability to survive in protozoa, mammalian macrophages, and inhospitable environmental niches and that may define new therapeutic targets.

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AN - SCOPUS:4644276577

SN - 0036-8075

VL - 305

SP - 1966

EP - 1968

JO - Science

JF - Science

IS - 5692

ER -

The genomic sequence of the accidental pathogen Legionella pneumophila

Abstract

Funding

UN SDGs

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