The Genetics of Conduction Disease

Roy Beinart, Jeremy Ruskin, David Milan

Research output: Contribution to journalReview articlepeer-review

Abstract

Conduction diseases (CD) include defects in impulse generation and conduction. Patients with CD may manifest a wide range of clinical presentations, from asymptomatic to potentially life-threatening arrhythmias. The pathophysiologic mechanisms underlying CD are diverse and may have implications for diagnosis, treatment, and prognosis. Known causes of functional CD include cardiac ion channelopathies or defects in modifying proteins, such as cytoskeletal proteins. Progress in molecular biology and genetics along with development of animal models has increased the understanding of the molecular mechanisms of these disorders. This article discusses the genetic basis for CD and its clinical implications.

Original languageEnglish
Pages (from-to)201-214
Number of pages14
JournalHeart Failure Clinics
Volume6
Issue number2
DOIs
StatePublished - Apr 2010
Externally publishedYes

Keywords

  • Atrioventricular
  • Conduction diseases
  • Genetics

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