@article{7a95c38fbc1a4aa3b79d19daed2b999c,
title = "The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus",
abstract = "The study aimed to explore the role of ERBB3 in type 1 diabetes (T1D). We examined whether genetic variation of ERBB3 (rs2292239) affects residual β-cell function in T1D cases. Furthermore, we examined the expression of ERBB3 in human islets, the effect of ERBB3 knockdown on apoptosis in insulin-producing INS-1E cells and the genetic and regulatory architecture of the ERBB3 locus to provide insights to how rs2292239 may confer disease susceptibility. rs2292239 strongly correlated with residual β-cell function and metabolic control in children with T1D. ERBB3 locus associated lncRNA (NONHSAG011351) was found to be expressed in human islets. ERBB3 was expressed and down-regulated by pro-inflammatory cytokines in human islets and INS-1E cells; knockdown of ERBB3 in INS-1E cells decreased basal and cytokine-induced apoptosis. Our data suggests an important functional role of ERBB3 and its potential regulators in the β-cells and may constitute novel targets to prevent β-cell destruction in T1D.",
keywords = "Apoptosis, Beta cell, CTCF, ERBB3, LncRNAs, Type 1 diabetes",
author = "{Hvidoere International Study Group} and Simranjeet Kaur and Mirza, {Aashiq H.} and Brorsson, {Caroline A.} and Tina Fl{\o}yel and Joachim St{\o}rling and Mortensen, {Henrik B.} and Flemming Pociot and Aanstoot, {Henk Jan} and {de Beaufort}, {Carine E.} and Fergus Cameron and Luis Castano and Harry Dorchy and Lynda Fisher and Eero Kaprio and Karin Lange and Andreas Neu and Njolstad, {Pal R.} and Moshe Phillip and Jean Robert and Tatsuhiko Urukami and Tim Barrett and Francesco Chiarelli and Thomas Danne and Hilary Hoey and Mirjana Kocova and Henrik Mortensen and Eugen Schoenle and Swift, {Peter F.} and Maurizio Vanelli and Jan {\AA}man",
note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Ireland Ltd.",
year = "2016",
month = jan,
day = "5",
doi = "10.1016/j.mce.2015.10.002",
language = "אנגלית",
volume = "419",
pages = "83--91",
journal = "Molecular and Cellular Endocrinology",
issn = "0303-7207",
publisher = "Elsevier Ireland Ltd",
}