The gene encoding vasoactive intestinal peptide is located on human chromosome 6p21→6qter

Illana Gozes, Rina Avidor, Yaakov Yahav, Daniel Katznelson, Carlo M. Croce, Kay Huebner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Vasoactive intestinal peptide (VIP) is a regulatory neuropeptide involved in a wide variety of functions, among them vasodilation, smooth muscle relaxation, sweat secretion, gastrointestinal peristalsis, and pancreatic function. A deficient VIP-innervation of sweat glands was recently described as a possible pathogenic factor in sweating of cystic fibrosis (CF) patients. To investigate a possible role for a defective VIP-gene in cystic fibrosis, we have used a panel of rodent-human hybrid cells, retaining defined complements of human chromosomes to localize the VIP-gene to the human chromosome region 6p21→6qter. As the CF gene was recently mapped to chromosome 7, we conclude that the VIP-gene is not the primary gene defect in this disease.

Original languageEnglish
Pages (from-to)41-44
Number of pages4
JournalHuman Genetics
Volume75
Issue number1
DOIs
StatePublished - Jan 1987
Externally publishedYes

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