The gene encoding vasoactive intestinal peptide is located on human chromosome 6p21→6qter

Illana Gozes; Rina Avidor; Yaakov Yahav; Daniel Katznelson; Carlo M. Croce; Kay Huebner

doi:10.1007/BF00273836

The gene encoding vasoactive intestinal peptide is located on human chromosome 6p21→6qter

Illana Gozes, Rina Avidor, Yaakov Yahav, Daniel Katznelson, Carlo M. Croce, Kay Huebner^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Vasoactive intestinal peptide (VIP) is a regulatory neuropeptide involved in a wide variety of functions, among them vasodilation, smooth muscle relaxation, sweat secretion, gastrointestinal peristalsis, and pancreatic function. A deficient VIP-innervation of sweat glands was recently described as a possible pathogenic factor in sweating of cystic fibrosis (CF) patients. To investigate a possible role for a defective VIP-gene in cystic fibrosis, we have used a panel of rodent-human hybrid cells, retaining defined complements of human chromosomes to localize the VIP-gene to the human chromosome region 6p21→6qter. As the CF gene was recently mapped to chromosome 7, we conclude that the VIP-gene is not the primary gene defect in this disease.

Original language	English
Pages (from-to)	41-44
Number of pages	4
Journal	Human Genetics
Volume	75
Issue number	1
DOIs	https://doi.org/10.1007/BF00273836
State	Published - Jan 1987
Externally published	Yes

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title = "The gene encoding vasoactive intestinal peptide is located on human chromosome 6p21→6qter",

abstract = "Vasoactive intestinal peptide (VIP) is a regulatory neuropeptide involved in a wide variety of functions, among them vasodilation, smooth muscle relaxation, sweat secretion, gastrointestinal peristalsis, and pancreatic function. A deficient VIP-innervation of sweat glands was recently described as a possible pathogenic factor in sweating of cystic fibrosis (CF) patients. To investigate a possible role for a defective VIP-gene in cystic fibrosis, we have used a panel of rodent-human hybrid cells, retaining defined complements of human chromosomes to localize the VIP-gene to the human chromosome region 6p21→6qter. As the CF gene was recently mapped to chromosome 7, we conclude that the VIP-gene is not the primary gene defect in this disease.",

author = "Illana Gozes and Rina Avidor and Yaakov Yahav and Daniel Katznelson and Croce, {Carlo M.} and Kay Huebner",

year = "1987",

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doi = "10.1007/BF00273836",

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AU - Gozes, Illana

AU - Avidor, Rina

AU - Yahav, Yaakov

AU - Katznelson, Daniel

AU - Croce, Carlo M.

AU - Huebner, Kay

PY - 1987/1

Y1 - 1987/1

N2 - Vasoactive intestinal peptide (VIP) is a regulatory neuropeptide involved in a wide variety of functions, among them vasodilation, smooth muscle relaxation, sweat secretion, gastrointestinal peristalsis, and pancreatic function. A deficient VIP-innervation of sweat glands was recently described as a possible pathogenic factor in sweating of cystic fibrosis (CF) patients. To investigate a possible role for a defective VIP-gene in cystic fibrosis, we have used a panel of rodent-human hybrid cells, retaining defined complements of human chromosomes to localize the VIP-gene to the human chromosome region 6p21→6qter. As the CF gene was recently mapped to chromosome 7, we conclude that the VIP-gene is not the primary gene defect in this disease.

AB - Vasoactive intestinal peptide (VIP) is a regulatory neuropeptide involved in a wide variety of functions, among them vasodilation, smooth muscle relaxation, sweat secretion, gastrointestinal peristalsis, and pancreatic function. A deficient VIP-innervation of sweat glands was recently described as a possible pathogenic factor in sweating of cystic fibrosis (CF) patients. To investigate a possible role for a defective VIP-gene in cystic fibrosis, we have used a panel of rodent-human hybrid cells, retaining defined complements of human chromosomes to localize the VIP-gene to the human chromosome region 6p21→6qter. As the CF gene was recently mapped to chromosome 7, we conclude that the VIP-gene is not the primary gene defect in this disease.

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The gene encoding vasoactive intestinal peptide is located on human chromosome 6p21→6qter

Abstract

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