TY - JOUR
T1 - The functional connectivity between the locust leg pattern generators and the subesophageal ganglion higher motor center
AU - Knebel, Daniel
AU - Rillich, Jan
AU - Nadler, Leonard
AU - Pflüger, Hans Joachim
AU - Ayali, Amir
N1 - Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2019/1/23
Y1 - 2019/1/23
N2 - Higher motor centers and central pattern generators (CPGs) interact in the control of coordinated leg movements during locomotion throughout the animal kingdom. The subesophageal ganglion (SEG) is one of the insect head ganglia reported to have a role in the control of walking behavior. Here we explored the functional relations between the SEG and the thoracic leg CPGs in the desert locust. Backfill staining revealed about 300 SEG descending interneurons (DINs) altogether. Recordings from an in-vitro isolated chain of thoracic ganglia, with intact or severed connections to the SEG, during pharmacological activation were used to determine how the SEG affects the centrally generated motor output to the legs. The SEG was demonstrated to both activate leg CPGs and synchronize their bilateral activity. The role of the SEG in insect locomotion is discussed in light of these findings.
AB - Higher motor centers and central pattern generators (CPGs) interact in the control of coordinated leg movements during locomotion throughout the animal kingdom. The subesophageal ganglion (SEG) is one of the insect head ganglia reported to have a role in the control of walking behavior. Here we explored the functional relations between the SEG and the thoracic leg CPGs in the desert locust. Backfill staining revealed about 300 SEG descending interneurons (DINs) altogether. Recordings from an in-vitro isolated chain of thoracic ganglia, with intact or severed connections to the SEG, during pharmacological activation were used to determine how the SEG affects the centrally generated motor output to the legs. The SEG was demonstrated to both activate leg CPGs and synchronize their bilateral activity. The role of the SEG in insect locomotion is discussed in light of these findings.
KW - Central pattern generator (CPG)
KW - Insect
KW - Intersegmental coordination
KW - Locomotion
KW - Locust
KW - Subesophageal ganglion (SEG)
UR - http://www.scopus.com/inward/record.url?scp=85056175733&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2018.10.060
DO - 10.1016/j.neulet.2018.10.060
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C2 - 30391322
AN - SCOPUS:85056175733
SN - 0304-3940
VL - 692
SP - 77
EP - 82
JO - Neuroscience Letters
JF - Neuroscience Letters
ER -