The first solid-phase synthesis of bis(oxazolinyl)pyridine ligands

Avi Weissberg, Baruch Halak, Moshe Portnoy*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


Chiral Pybox (pyridine-2,6-bis(oxazoline)) ligands can be cleanly and efficiently prepared on polystyrene support via a five-step solid-phase synthetic sequence. Cu(I)-complexed polymer-bound Pybox was used as a catalyst in the first heterogeneously catalyzed asymmetric addition of alkynes to imines. Best enantioselectivity was observed with tBu-substituted oxazolines.

Original languageEnglish
Pages (from-to)4556-4559
Number of pages4
JournalJournal of Organic Chemistry
Issue number11
StatePublished - 27 May 2005


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