The fine-tuning of anti-oxidized low-density lipoprotein antibodies in cardiovascular disease and thrombosis

Jozélio Freire de Carvalho, Yaniv Sherer, Yehuda Shoenfeld

Research output: Contribution to journalReview articlepeer-review

Abstract

Anti-oxidised low-density lipoprotein (anti-oxLDL) antibodies are a heterogeneous group of autoantibodies including both pathogenic and protective subsets. Whereas in most studies the levels of anti-oxLDL antibodies were associated with enhanced atherosclerosis as evaluated by different methods, immunization with oxLDL leads to elevated levels of anti-oxLDL and protection against atherosclerosis. Anti-oxLDL can also be used for immunomodulation of atherosclerosis (i.e. possible therapeutic use of intravenous immunoglobulin, oral tolerance). More specific autoantibodies out of total anti-oxLDL should be selected, for instance, anti-oxLDL/beta-2-glycoprotein I complex, hence defining the fine-tuning of anti-oxLDL antibodies might detect which autoantibodies are pathogenic and which can be used therapeutically.

Original languageEnglish
Pages (from-to)1157-1159
Number of pages3
JournalThrombosis and Haemostasis
Volume98
Issue number6
DOIs
StatePublished - Dec 2007

Keywords

  • Anti-oxLDL
  • Autoantibodies
  • Cardiovascular diseases
  • Lipoproteins
  • oxLDL

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