TY - JOUR
T1 - The fetal inflammatory response syndrome
AU - Gotsch, Francesca
AU - Romero, Roberto
AU - Kusanovic, Juan Pedro
AU - Mazaki-Tovi, Shali
AU - Pineles, Beth L.
AU - Erez, Offer
AU - Espinoza, Jimmy
AU - Hassan, Sonia S.
PY - 2007/9
Y1 - 2007/9
N2 - The fetal inflammatory response syndrome (FIRS) is a condition characterized by systemic inflammation and an elevation of fetal plasma interleukin-6. This syndrome has been observed in fetuses with preterm labor with intact membranes, preterm prelabor rupture of the membranes, and also fetal viral infections such as cytomegalovirus. FIRS is a risk factor for short-term perinatal morbidity and mortality after adjustment for gestational age at delivery and also for the development of long-term sequelae such as bronchopulmonary dysplasia and brain injury. Multiorgan involvement in FIRS has been demonstrated in the hematopoietic system, thymus, adrenal glands, skin, kidneys, heart, lung, and brain. This article reviews the fetal systemic inflammatory response as a mechanism of disease. Potential interventions to control an exaggerated inflammatory response in utero are also described.
AB - The fetal inflammatory response syndrome (FIRS) is a condition characterized by systemic inflammation and an elevation of fetal plasma interleukin-6. This syndrome has been observed in fetuses with preterm labor with intact membranes, preterm prelabor rupture of the membranes, and also fetal viral infections such as cytomegalovirus. FIRS is a risk factor for short-term perinatal morbidity and mortality after adjustment for gestational age at delivery and also for the development of long-term sequelae such as bronchopulmonary dysplasia and brain injury. Multiorgan involvement in FIRS has been demonstrated in the hematopoietic system, thymus, adrenal glands, skin, kidneys, heart, lung, and brain. This article reviews the fetal systemic inflammatory response as a mechanism of disease. Potential interventions to control an exaggerated inflammatory response in utero are also described.
KW - Chorioamnionitis
KW - Funisitis
KW - Intrauterine infection
KW - PROM
KW - Premature birth
KW - Prematurity
KW - Preterm labor
UR - http://www.scopus.com/inward/record.url?scp=34548445957&partnerID=8YFLogxK
U2 - 10.1097/GRF.0b013e31811ebef6
DO - 10.1097/GRF.0b013e31811ebef6
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C2 - 17762416
AN - SCOPUS:34548445957
SN - 0009-9201
VL - 50
SP - 652
EP - 683
JO - Clinical Obstetrics and Gynecology
JF - Clinical Obstetrics and Gynecology
IS - 3
ER -
