The feasibility of nuchal translucency measurement in higher order multiple gestations achieved by assisted reproduction

R. Maymon*, E. Dreazen, Y. Tovbin, I. Bukovsky, Z. Weinraub, A. Herman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Nuchal translucency (NT) measurement for screening chromosomal abnormalities and detecting fetal anomalies is an effective ultrasonographic marker, originally developed for singleton pregnancies. This study sought to evaluate the feasibility of NT measurements in higher order multiple gestations. Pregnant patients who conceived following assisted reproduction and were carrying three or more fetuses were enrolled in the study. Each fetus was ultrasonographically assessed, a NT measurement was obtained, and the findings were used for counselling prior to any invasive procedure. In all, 24 pregnant patients, initially carrying 79 fetuses aged 10-14 weeks of gestation, were compared with 79 consecutively matched, singleton controls, naturally conceived, having similar crown-rump lengths (± 3 mm). NT measurements were feasible for both study and control fetuses, which exhibited similar NT measurements for 5th, 50th and 95th centiles. Also, mean NT thicknesses [measurements in mm or multiple of the medians (MOM)] were similar for both groups (1.41 ± 0.41 and 1.35 ± 0.39 mm respectively and 0.87 ± 0.23 and 0.83 ± 0.25 MOM respectively). Prenatally no chromosomal abnormalities were detected in either group, and, of those infants who had no karyotyping, no traits were observed that warranted chromosomal analysis. NT measurements are feasible in higher order multiple gestations. Since there is no other effective screening modality for these pregnancies, it seems reasonable to recommend NT measurement for antenatal screening services for higher order multiple gestations.

Original languageEnglish
Pages (from-to)2102-2105
Number of pages4
JournalHuman Reproduction
Volume14
Issue number8
DOIs
StatePublished - 1999

Keywords

  • Multiplicity of higher order gestations
  • Nuchal translucency
  • Ultrasound

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