The Fate of Altered Hepatocytic Foci as a Result of Treatment with Oxodipine, a Calcium Channel Blocker

Abraham Nyska; Trevor Waner; Alvaro Galiano; Baruch Klein

doi:10.1111/j.1600-0773.1992.tb00504.x

The Fate of Altered Hepatocytic Foci as a Result of Treatment with Oxodipine, a Calcium Channel Blocker

Abraham Nyska, Trevor Waner, Alvaro Galiano, Baruch Klein

Clinical Departments

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Abstract

Abstract: The dietary administration of the calcium channel blocker oxodipine to Fischer (F344) rats for 12 and 30 months resulted in increased incidence of altered hepatocytic foci (AHF). As the Environmental Protection Agency (EPA) regards AHF as potentially precancerous it is important to accumulate experimental evidence which may negate this theory. In the case of oxodipine we proved that with dosages close to maximum tolerated dose (MTD) for prolonged periods no hepatic neoplasms were produced. The possible nature of such AHF is discussed. 1992 Nordic Pharmacological Society

Original language	English
Pages (from-to)	439-442
Number of pages	4
Journal	Basic and Clinical Pharmacology and Toxicology
Volume	70
Issue number	6
DOIs	https://doi.org/10.1111/j.1600-0773.1992.tb00504.x
State	Published - Jun 1992

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abstract = "Abstract: The dietary administration of the calcium channel blocker oxodipine to Fischer (F344) rats for 12 and 30 months resulted in increased incidence of altered hepatocytic foci (AHF). As the Environmental Protection Agency (EPA) regards AHF as potentially precancerous it is important to accumulate experimental evidence which may negate this theory. In the case of oxodipine we proved that with dosages close to maximum tolerated dose (MTD) for prolonged periods no hepatic neoplasms were produced. The possible nature of such AHF is discussed. 1992 Nordic Pharmacological Society",

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The Fate of Altered Hepatocytic Foci as a Result of Treatment with Oxodipine, a Calcium Channel Blocker

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