@article{a0f38bdf671644108424e2a19771d485,
title = "The excludon: A new concept in bacterial antisense RNA-mediated gene regulation",
abstract = "In recent years, non-coding RNAs have emerged as key regulators of gene expression. Among these RNAs, the antisense RNAs (asRNAs) are particularly abundant, but in most cases the function and mechanism of action for a particular asRNA remains elusive. Here, we highlight a recently discovered paradigm termed the excludon, which defines a genomic locus encoding an unusually long asRNA that spans divergent genes or operons with related or opposing functions. Because these asRNAs can inhibit the expression of one operon while functioning as an mRNA for the adjacent operon, they act as fine-tuning regulatory switches in bacteria.",
author = "Nina Sesto and Omri Wurtzel and Cristel Archambaud and Rotem Sorek and Pascale Cossart",
note = "Funding Information: The authors thank J. Mellin for insightful discussions. This work was supported by the Pasteur–Weizmann programme (grants to P.C. and R.S.), the European Research Council (Advanced Grant 233348 to P.C. and Starting Grant 260432 to R.S.), the French Agence Nationale de la Recherche (grants Bacregrna 09-BLAN-0024-02 to P.C. and BacNet 10-BINF-02-01 to P.C. and N.S.), the Fondation Le Roch Les Mousquetaires (P.C.), the Fondation Louis-Jeantet (P.C.), the German Minerva Foundation (R.S.), the Deutsche Forschungsgemeinschaft (a German–Isaraeli Project Cooperation grant to R.S.), the French Institute National de la Recherche Agronomique (a fellowship to N.S.) and the Azrieli Foundation (a fellowship to O.W.).",
year = "2013",
month = feb,
doi = "10.1038/nrmicro2934",
language = "אנגלית",
volume = "11",
pages = "75--82",
journal = "Nature Reviews Microbiology",
issn = "1740-1526",
publisher = "Nature Publishing Group",
number = "2",
}
