The evolutionary history of the sarafotoxin/endothelin/endothelin-like superfamily

G. Landan, A. Bdolah, Z. Wollberg, E. Kochva, D. Graur*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The evolutionary relationships among 17 protein and nucleic acid sequences from the sarafotoxin/endothelin/endothelin-Like superfamily of peptides were studied. The endothelin/endothelin-Like gene family has diverged from an ancestral gene that has experienced an exon duplication event followed by two complete gene duplications. The sarafotoxin lineage diverged from the ancestral gene prior to the first gene duplication event. In several lineages, the peptides have independently accumulated identical amino acid replacements in position 2. This finding supports the hypothesis that residue 2 is crucial to biological activity.

Original languageEnglish
Pages (from-to)S517-S519
JournalJournal of Cardiovascular Pharmacology
StatePublished - 1991


  • Ancestral gene
  • Endothelins
  • Residue 2
  • Sarafotoxin


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