The evolution of toxic anterior segment syndrome

Karny Shouchane-Blum, Assaf Dotan, Irit Bahar*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Purpose of reviewToxic anterior segment syndrome (TASS) is a surgical complication resulting from a noninfectious inflammatory reaction to substances used during intraocular ophthalmic surgery. Continuous reporting of new information concerning risk factors and possible causes is critical for preventing this condition.Recent findingsThe diagnosis of TASS is clinical and its main features are well known. However, new causes of TASS are emerging and being reported, as are new treatment options for managing the inflammation or its complications, and prevention guidelines are being updated. This article presents current and novel information regarding these topics.SummaryEducating the medical community regarding potential causes of TASS and its prevention is necessary for improving management of TASS. Thorough investigations and reports of TASS cases are a fundamental step in achieving this goal. Still, as the complete eradication of TASS solely through prevention is unlikely, further studies regarding TASS's pathophysiology, systemic and ocular risk factors, and new treatment options are necessary.

Original languageEnglish
Pages (from-to)50-55
Number of pages6
JournalCurrent Opinion in Ophthalmology
Issue number1
StatePublished - 1 Jan 2019


  • guidelines
  • risk factors
  • toxic anterior segment syndrome
  • treatment


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