The evolution of stress-induced hypermutation in asexual populations

Yoav Ram, Lilach Hadany*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

73 Scopus citations


Numerous empirical studies show that stress of various kinds induces a state of hypermutation in bacteria via multiple mechanisms, but theoretical treatment of this intriguing phenomenon is lacking. We used deterministic and stochastic models to study the evolution of stress-induced hypermutation in infinite and finite-size populations of bacteria undergoing selection, mutation, and random genetic drift in constant environments and in changing ones. Our results suggest that if beneficial mutations occur, even rarely, then stress-induced hypermutation is advantageous for bacteria at both the individual and the population levels and that it is likely to evolve in populations of bacteria in a wide range of conditions because it is favored by selection. These results imply that mutations are not, as the current view holds, uniformly distributed in populations, but rather that mutations are more common in stressed individuals and populations. Because mutation is the raw material of evolution, these results have a profound impact on broad aspects of evolution and biology.

Original languageEnglish
Pages (from-to)2315-2328
Number of pages14
Issue number7
StatePublished - Jul 2012


  • Evolvability
  • Genetic variation
  • Mathematical models/simulations
  • Mutagenesis
  • Phenotypic plasticity
  • Population genetics


Dive into the research topics of 'The evolution of stress-induced hypermutation in asexual populations'. Together they form a unique fingerprint.

Cite this