The evaluation of the anti autistic activity of sulpiride

A. Elizur, S. Davidson

Research output: Contribution to journalArticlepeer-review

Abstract

A trial was carried out on fourteen hospitalized schizophrenic patients with the drug sulpiride in order to evaluate its specificity in combating the target symptoms of apathy and withdrawal. Weekly evaluations were made by two psychiatrists independently during the trial period of seven weeks. In the first week, a placebo was administered, in the second week 800 mg. sulpiride intramuscularly daily, this being continued orally for the next five weeks of the trial. In five of the fourteen patients, marked improvement in their autistic state appeared in the second and third weeks of treatment and they were fit to be discharged from hospital at the end of the seven week study period. They became less inhibited, apathetic and withdrawn, mood improved, and they responded to social and occupational therapy. No ataractic effects were evident and, in fact, the drugs may aggravate or even precipitate anxiety and delusional manifestations. The mood improvement in the authors' opinion was a result of the general anti autistic effect of the sulpiride.

Original languageEnglish
Pages (from-to)578-584
Number of pages7
JournalCurrent Therapeutic Research
Volume18
Issue number4
StatePublished - 1975

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