The estrogen receptors in the papillary carcinoma of the thyroid gland

Michael Vaiman; Youlian Olevson; Liliana Habler; Ephraim Eviatar; Sergei Zehari; Judith Sandbank; Alex Kessler

doi:10.3727/096504010X12767359113802

The estrogen receptors in the papillary carcinoma of the thyroid gland

Michael Vaiman^*, Youlian Olevson, Liliana Habler, Ephraim Eviatar, Sergei Zehari, Judith Sandbank, Alex Kessler

^*Corresponding author for this work

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Abstract

In this study, the objective was to evaluate the presence of estrogen receptors α and β (ERα and ERβ) in cases of papillary carcinoma of the thyroid gland and to assess the practicality of this test. Immunohistochemical stains were performed for both ERα and ERβ, for evaluation of immunoreactivity in 90 papillary carcinomas. Three variables were evaluated in each sample: the intensity of the staining both nuclear and cytoplasmatic, and the spread of the stain over the sample. None of the histological samples showed immunoreactivity for ERα. Positive immunoreactivity results for ERβ were found in tissue samples in 66.6% (60 cases). The study shows that ERβ has no significant specification for differentiation between papillary carcinoma and other malignant lesions of the thyroid, while ERα is undetectable in this lesion. The ER testing in cases of papillary carcinoma of the thyroid gland is nonspecific and might be not necessary.

Original language	English
Pages (from-to)	537-540
Number of pages	4
Journal	Oncology Research
Volume	18
Issue number	11-12
DOIs	https://doi.org/10.3727/096504010X12767359113802
State	Published - 2010
Externally published	Yes

Keywords

Estrogen receptors
Papillary carcinoma
Thyroid gland

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10.3727/096504010X12767359113802

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AU - Vaiman, Michael

AU - Olevson, Youlian

AU - Habler, Liliana

AU - Eviatar, Ephraim

AU - Zehari, Sergei

AU - Sandbank, Judith

AU - Kessler, Alex

PY - 2010

Y1 - 2010

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The estrogen receptors in the papillary carcinoma of the thyroid gland

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