The estrogen receptors in the papillary carcinoma of the thyroid gland

Michael Vaiman*, Youlian Olevson, Liliana Habler, Ephraim Eviatar, Sergei Zehari, Judith Sandbank, Alex Kessler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

In this study, the objective was to evaluate the presence of estrogen receptors α and β (ERα and ERβ) in cases of papillary carcinoma of the thyroid gland and to assess the practicality of this test. Immunohistochemical stains were performed for both ERα and ERβ, for evaluation of immunoreactivity in 90 papillary carcinomas. Three variables were evaluated in each sample: the intensity of the staining both nuclear and cytoplasmatic, and the spread of the stain over the sample. None of the histological samples showed immunoreactivity for ERα. Positive immunoreactivity results for ERβ were found in tissue samples in 66.6% (60 cases). The study shows that ERβ has no significant specification for differentiation between papillary carcinoma and other malignant lesions of the thyroid, while ERα is undetectable in this lesion. The ER testing in cases of papillary carcinoma of the thyroid gland is nonspecific and might be not necessary.

Original languageEnglish
Pages (from-to)537-540
Number of pages4
JournalOncology Research
Volume18
Issue number11-12
DOIs
StatePublished - 2010
Externally publishedYes

Keywords

  • Estrogen receptors
  • Papillary carcinoma
  • Thyroid gland

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