TY - JOUR
T1 - The establishment of an ovum donation program using a simple fixed-dose estrogen-progesterone replacement regimen
AU - Kogosowski, Abraham
AU - Yovel, Israel
AU - Lessing, Joseph B.
AU - Amit, Ami
AU - Barak, Yona
AU - David, Menachem P.
AU - Peyser, Reuben
PY - 1990/10
Y1 - 1990/10
N2 - Most ovum donation (OD) programs involve cycle synchronization between recipient and donor for normally cycling recipients and a complex estrogen-progesterone replacement regimen for recipients with ovarian failure. In 1987, Serhal and Craft (1) suggested the use of a fixeddose estrogen-progesterone regimen for recipients who were normally ovulatory and to those with ovarian failure. Following this protocol, and simplifying it still, the authors administered 6 mg estradiol valerate (E2) daily orally starting on day 2-6 of induced withdrawal bleeding, augmented with 100 mg progesterone in ethyl oleate (P) intramuscularly daily, starting any time between 4 days prior to and the day of oocyte pickup. All recipients underwent embryo transfer at a 2-pronuclei (2PN)-10-cell stage. A group of 21 patients underwent 26 treatment cycles, resulting in 16 pregnancies. Twelve of the patients gave birth, one to triplets, two to twins, and nine to singletons. Four patients miscarried in the first trimester of pregnancy.
AB - Most ovum donation (OD) programs involve cycle synchronization between recipient and donor for normally cycling recipients and a complex estrogen-progesterone replacement regimen for recipients with ovarian failure. In 1987, Serhal and Craft (1) suggested the use of a fixeddose estrogen-progesterone regimen for recipients who were normally ovulatory and to those with ovarian failure. Following this protocol, and simplifying it still, the authors administered 6 mg estradiol valerate (E2) daily orally starting on day 2-6 of induced withdrawal bleeding, augmented with 100 mg progesterone in ethyl oleate (P) intramuscularly daily, starting any time between 4 days prior to and the day of oocyte pickup. All recipients underwent embryo transfer at a 2-pronuclei (2PN)-10-cell stage. A group of 21 patients underwent 26 treatment cycles, resulting in 16 pregnancies. Twelve of the patients gave birth, one to triplets, two to twins, and nine to singletons. Four patients miscarried in the first trimester of pregnancy.
KW - in vitro fertilization (IVF)
KW - ovum donation
KW - replacement regimen
UR - http://www.scopus.com/inward/record.url?scp=0025114597&partnerID=8YFLogxK
U2 - 10.1007/BF01129527
DO - 10.1007/BF01129527
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C2 - 2254686
AN - SCOPUS:0025114597
SN - 0740-7769
VL - 7
SP - 244
EP - 248
JO - Journal of in Vitro Fertilization and Embryo Transfer
JF - Journal of in Vitro Fertilization and Embryo Transfer
IS - 5
ER -