The erythrocyte membrane in essential hypertension. Modified temperature-dependence of Li+ efflux

Rachel Levy; Reuven Zimlichman; Arie Keynan; Avinoam Livne

doi:10.1016/0005-2736(82)90102-X

The erythrocyte membrane in essential hypertension. Modified temperature-dependence of Li⁺ efflux

Rachel Levy
, Reuven Zimlichman
, Arie Keynan
, Avinoam Livne^*

^*Corresponding author for this work

Ben-Gurion University of the Negev

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The rate of ouabain-resistant Li⁺-efflux was studied in erythrocytes of normal controls and of patients with essential hypertension. Despite variability in rate, erythrocytes from normotensive persons revealed a uniform pattern of temperature dependence of the efflux, with two slopes (K_a = 9.4 and 19.1 kcal/mol, respectively) and a transition at about 25°C. Erythrocytes from the patients showed both a higher rate of Li⁺ efflux and significant changes in the temperature repsonse, with essentially a single slope (K_a = 14 kcal/mol). The data indicate localized changes in the membrane organization of hypertensive erythrocytes, involving lipid-protein interaction.

Original language	English
Pages (from-to)	214-218
Number of pages	5
Journal	BBA - Biomembranes
Volume	685
Issue number	2
DOIs	https://doi.org/10.1016/0005-2736(82)90102-X
State	Published - 23 Feb 1982
Externally published	Yes

Keywords

(Human erythrocyte membrane)
Hypertension
Li efflux
Temperature dependence

Access to Document

10.1016/0005-2736(82)90102-X

Cite this

@article{dcd6ecc7f8e44c97b4c8647adfcb359f,

title = "The erythrocyte membrane in essential hypertension. Modified temperature-dependence of Li+ efflux",

abstract = "The rate of ouabain-resistant Li+-efflux was studied in erythrocytes of normal controls and of patients with essential hypertension. Despite variability in rate, erythrocytes from normotensive persons revealed a uniform pattern of temperature dependence of the efflux, with two slopes (Ka = 9.4 and 19.1 kcal/mol, respectively) and a transition at about 25°C. Erythrocytes from the patients showed both a higher rate of Li+ efflux and significant changes in the temperature repsonse, with essentially a single slope (Ka = 14 kcal/mol). The data indicate localized changes in the membrane organization of hypertensive erythrocytes, involving lipid-protein interaction.",

keywords = "(Human erythrocyte membrane), Hypertension, Li efflux, Temperature dependence",

author = "Rachel Levy and Reuven Zimlichman and Arie Keynan and Avinoam Livne",

year = "1982",

month = feb,

day = "23",

doi = "10.1016/0005-2736(82)90102-X",

language = "אנגלית",

volume = "685",

pages = "214--218",

journal = "BBA - Biomembranes",

issn = "0005-2736",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - The erythrocyte membrane in essential hypertension. Modified temperature-dependence of Li+ efflux

AU - Levy, Rachel

AU - Zimlichman, Reuven

AU - Keynan, Arie

AU - Livne, Avinoam

PY - 1982/2/23

Y1 - 1982/2/23

N2 - The rate of ouabain-resistant Li+-efflux was studied in erythrocytes of normal controls and of patients with essential hypertension. Despite variability in rate, erythrocytes from normotensive persons revealed a uniform pattern of temperature dependence of the efflux, with two slopes (Ka = 9.4 and 19.1 kcal/mol, respectively) and a transition at about 25°C. Erythrocytes from the patients showed both a higher rate of Li+ efflux and significant changes in the temperature repsonse, with essentially a single slope (Ka = 14 kcal/mol). The data indicate localized changes in the membrane organization of hypertensive erythrocytes, involving lipid-protein interaction.

AB - The rate of ouabain-resistant Li+-efflux was studied in erythrocytes of normal controls and of patients with essential hypertension. Despite variability in rate, erythrocytes from normotensive persons revealed a uniform pattern of temperature dependence of the efflux, with two slopes (Ka = 9.4 and 19.1 kcal/mol, respectively) and a transition at about 25°C. Erythrocytes from the patients showed both a higher rate of Li+ efflux and significant changes in the temperature repsonse, with essentially a single slope (Ka = 14 kcal/mol). The data indicate localized changes in the membrane organization of hypertensive erythrocytes, involving lipid-protein interaction.

KW - (Human erythrocyte membrane)

KW - Hypertension

KW - Li efflux

KW - Temperature dependence

UR - https://www.scopus.com/pages/publications/0020064383

U2 - 10.1016/0005-2736(82)90102-X

DO - 10.1016/0005-2736(82)90102-X

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:0020064383

SN - 0005-2736

VL - 685

SP - 214

EP - 218

JO - BBA - Biomembranes

JF - BBA - Biomembranes

IS - 2

ER -

The erythrocyte membrane in essential hypertension. Modified temperature-dependence of Li⁺ efflux

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this