The erythrocyte adhesiveness/aggregation test to reveal real-time information of rheological relevance in patients with familial and primary hypercholesterolemia before and following plasma exchange

Tiberiu Hershcovici, Keren Elishkevitz, Rivka Rotstein, Renato Fusman, David Zeltser, Itzhak Shapira, Nadir Arber, Daniel Avitzour, Shlomo Berliner, Yitzhak Beigel

Research output: Contribution to journalArticlepeer-review

Abstract

We applied an erythrocyte adhesiveness/aggregation test (EAAT) to a model of plasma exchange in individuals with familial and primary hypercholesterolemia. The significant (p < 0.0001) reduction in the concentration of fibrinogen by 56%, globulins by 48%, and cholesterol by 53% corresponded to the expected significant (p < 0.0001) reduction in the degree of erythrocyte adhesiveness/aggregation in the peripheral venous blood. By virtue of its being a real-time, simple, very-low-cost, and essentially bedside technique, the EAAT might have the potential of disclosing information of rheological relevance immediately before, during, as well as following apheretical procedures administered to patients with an impaired rheological profile.

Original languageEnglish
Pages (from-to)140-144
Number of pages5
JournalTherapeutic Apheresis
Volume6
Issue number2
DOIs
StatePublished - 2002

Keywords

  • Erythrocyte adhesiveness/aggregation
  • Hypercholesterolemia
  • Plasma exchange

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