TY - JOUR
T1 - The epitranscriptome in translation regulation
AU - Peer, Eyal
AU - Moshitch-Moshkovitz, Sharon
AU - Rechavi, Gideon
AU - Dominissini, Dan
N1 - Publisher Copyright:
© 2019 Cold Spring Harbor Laboratory Press; all rights reserved;.
PY - 2019/8
Y1 - 2019/8
N2 - The cellular proteome reflects the total outcome of many regulatory mechanisms that affect the metabolism of messenger RNA (mRNA) along its pathway from synthesis to degradation. Accumulating evidence in recent years has uncovered the roles of a growing number of mRNA modifications in every step along this pathway, shaping translational output. mRNA modifications affect the translation machinery directly, by influencing translation initiation, elongation and termination, or by altering mRNA levels and subcellular localization. Features of modification-related translational control are described, charting a new and complex layer of translational regulation.
AB - The cellular proteome reflects the total outcome of many regulatory mechanisms that affect the metabolism of messenger RNA (mRNA) along its pathway from synthesis to degradation. Accumulating evidence in recent years has uncovered the roles of a growing number of mRNA modifications in every step along this pathway, shaping translational output. mRNA modifications affect the translation machinery directly, by influencing translation initiation, elongation and termination, or by altering mRNA levels and subcellular localization. Features of modification-related translational control are described, charting a new and complex layer of translational regulation.
UR - http://www.scopus.com/inward/record.url?scp=85070828290&partnerID=8YFLogxK
U2 - 10.1101/cshperspect.a032623
DO - 10.1101/cshperspect.a032623
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AN - SCOPUS:85070828290
SN - 1943-0264
VL - 11
JO - Cold Spring Harbor perspectives in biology
JF - Cold Spring Harbor perspectives in biology
IS - 8
M1 - a032623
ER -