The epitranscriptome in translation regulation

Eyal Peer, Sharon Moshitch-Moshkovitz, Gideon Rechavi, Dan Dominissini

Research output: Contribution to journalArticlepeer-review

Abstract

The cellular proteome reflects the total outcome of many regulatory mechanisms that affect the metabolism of messenger RNA (mRNA) along its pathway from synthesis to degradation. Accumulating evidence in recent years has uncovered the roles of a growing number of mRNA modifications in every step along this pathway, shaping translational output. mRNA modifications affect the translation machinery directly, by influencing translation initiation, elongation and termination, or by altering mRNA levels and subcellular localization. Features of modification-related translational control are described, charting a new and complex layer of translational regulation.

Original languageEnglish
Article numbera032623
JournalCold Spring Harbor perspectives in biology
Volume11
Issue number8
DOIs
StatePublished - Aug 2019

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