The epidemiological, clinical, and histopathological characteristics of lacrimal gland biopsies in a tertiary care center in Israel

Ayelet Priel*, Vicktoria Vishnevskia-Dai, Liran Hochma, Juliana Gildener-Leapman, Guy J. Ben Simon, Mordechai Rosner, Gal Antman, Ofira Zloto

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background: The distribution of pathology and clinical characteristics of lacrimal gland diseases are different in different areas of the world. Objectives: To evaluate the incidence rate, patient characteristics, and indications for surgical intervention of lacrimal gland lesions in a tertiary care center in Israel. Methods: All biopsied or surgically removed lacrimal gland lesions at the Goldschleger Eye Institute from 2009 to 2015 were identified. The following data were collected: age, gender, indications for surgical intervention, diagnosis, treatment, and prognosis. Results: We evaluated 28 lacrimal gland biopsies from 26 patients (11 men, 15 women). Mean age at biopsy was 47.5 years old. The most common presenting symptoms were: eyelid swollenness (57.14%), ptosis (32.14%), and proptosis (10.71%). All patients underwent computed tomography and magnetic resonance imaging. In 28 cases, infiltrations of the lacrimal gland were found. In nine cases infiltration of muscles or orbital extension were found. The most common pathologies were non-specified inflammation (44.82%), lymphoma (20.68%), and immunoglobulin G4-related disease (10.34%). The treatment was diverse according to the patient diagnosis. Prognosis of lacrimal gland disease was good; however, in five patients the systemic disease progressed. Conclusions: Lesions of the lacrimal gland comprise a wide variety of pathological findings that require different treatment strategies. Lacrimal gland biopsies enable physicians to precisely recognize the pathology; therefore, it is important to consider this surgical method in any patient with lesions in the lacrimal gland.

Original languageEnglish
Pages (from-to)104-108
Number of pages5
JournalIsrael Medical Association Journal
Volume20
Issue number2
StatePublished - Feb 2018

Keywords

  • Immunoglobulin G4-related disease (IgG4-RD)
  • Lacrimal gland
  • Lymphoma
  • Proptosis
  • Ptosis

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