TY - JOUR
T1 - The epidemiological, clinical, and histopathological characteristics of lacrimal gland biopsies in a tertiary care center in Israel
AU - Priel, Ayelet
AU - Vishnevskia-Dai, Vicktoria
AU - Hochma, Liran
AU - Gildener-Leapman, Juliana
AU - Ben Simon, Guy J.
AU - Rosner, Mordechai
AU - Antman, Gal
AU - Zloto, Ofira
N1 - Publisher Copyright:
© 2018, Israel Medical Association. All rights reserved.
PY - 2018/2
Y1 - 2018/2
N2 - Background: The distribution of pathology and clinical characteristics of lacrimal gland diseases are different in different areas of the world. Objectives: To evaluate the incidence rate, patient characteristics, and indications for surgical intervention of lacrimal gland lesions in a tertiary care center in Israel. Methods: All biopsied or surgically removed lacrimal gland lesions at the Goldschleger Eye Institute from 2009 to 2015 were identified. The following data were collected: age, gender, indications for surgical intervention, diagnosis, treatment, and prognosis. Results: We evaluated 28 lacrimal gland biopsies from 26 patients (11 men, 15 women). Mean age at biopsy was 47.5 years old. The most common presenting symptoms were: eyelid swollenness (57.14%), ptosis (32.14%), and proptosis (10.71%). All patients underwent computed tomography and magnetic resonance imaging. In 28 cases, infiltrations of the lacrimal gland were found. In nine cases infiltration of muscles or orbital extension were found. The most common pathologies were non-specified inflammation (44.82%), lymphoma (20.68%), and immunoglobulin G4-related disease (10.34%). The treatment was diverse according to the patient diagnosis. Prognosis of lacrimal gland disease was good; however, in five patients the systemic disease progressed. Conclusions: Lesions of the lacrimal gland comprise a wide variety of pathological findings that require different treatment strategies. Lacrimal gland biopsies enable physicians to precisely recognize the pathology; therefore, it is important to consider this surgical method in any patient with lesions in the lacrimal gland.
AB - Background: The distribution of pathology and clinical characteristics of lacrimal gland diseases are different in different areas of the world. Objectives: To evaluate the incidence rate, patient characteristics, and indications for surgical intervention of lacrimal gland lesions in a tertiary care center in Israel. Methods: All biopsied or surgically removed lacrimal gland lesions at the Goldschleger Eye Institute from 2009 to 2015 were identified. The following data were collected: age, gender, indications for surgical intervention, diagnosis, treatment, and prognosis. Results: We evaluated 28 lacrimal gland biopsies from 26 patients (11 men, 15 women). Mean age at biopsy was 47.5 years old. The most common presenting symptoms were: eyelid swollenness (57.14%), ptosis (32.14%), and proptosis (10.71%). All patients underwent computed tomography and magnetic resonance imaging. In 28 cases, infiltrations of the lacrimal gland were found. In nine cases infiltration of muscles or orbital extension were found. The most common pathologies were non-specified inflammation (44.82%), lymphoma (20.68%), and immunoglobulin G4-related disease (10.34%). The treatment was diverse according to the patient diagnosis. Prognosis of lacrimal gland disease was good; however, in five patients the systemic disease progressed. Conclusions: Lesions of the lacrimal gland comprise a wide variety of pathological findings that require different treatment strategies. Lacrimal gland biopsies enable physicians to precisely recognize the pathology; therefore, it is important to consider this surgical method in any patient with lesions in the lacrimal gland.
KW - Immunoglobulin G4-related disease (IgG4-RD)
KW - Lacrimal gland
KW - Lymphoma
KW - Proptosis
KW - Ptosis
UR - http://www.scopus.com/inward/record.url?scp=85042112100&partnerID=8YFLogxK
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AN - SCOPUS:85042112100
SN - 1565-1088
VL - 20
SP - 104
EP - 108
JO - Israel Medical Association Journal
JF - Israel Medical Association Journal
IS - 2
ER -