The energy status of astrocytes is the achilles’ heel of eif2b-leukodystrophy

Keyphrases

• Astrocytes 100%
• Achilles Heel 100%
• Eukaryotic Initiation Factor 2B (eIF2B) 100%
• IDH1-R132H 100%
• Leukodystrophy 100%
• Energy Status 100%
• Reactive Oxygen Species 40%
• ATP Level 40%
• Oxidative Stress 20%
• Enzymatic Activity 20%
• Adaptation 20%
• HyPer 20%
• Mammalian Target of Rapamycin (mTOR) 20%
• Cancer Cells 20%
• Fibroblasts 20%
• Master Regulator 20%
• Glycolysis 20%
• Protein Synthesis 20%
• AMP-activated Protein Kinase 20%
• Primary Fibroblasts 20%
• Hypomorphic mutation 20%
• Neurodegenerative 20%
• Translation Initiation Factor 20%
• Vanishing White Matter Disease 20%
• Mitochondrial Electron Transport Chain 20%
• Oxidative Phosphorylation (OXPHOS) 20%
• Glucose Starvation 20%
• Mitochondrial Biogenesis 20%
• Primary Astrocytes 20%
• Metabolic Homeostasis 20%
• Redox Homeostasis 20%
• Energy Stress 20%
• Cellular ATP 20%
• Chain Complex 20%
• Metabolic Impairment 20%

Neuroscience

• Astrocyte 100%
• Leukodystrophy 100%
• Reactive Oxygen Species 40%
• Adenosine Triphosphate 40%
• Fibroblast 40%
• Oxidative Stress 20%
• AMP-activated Protein Kinase 20%
• Enzyme Activity 20%
• Protein Biosynthesis 20%
• Translation Initiation 20%
• White Matter Disease 20%
• Oxidative Phosphorylation 20%
• Electron Transport Chain 20%
• Guanine Nucleotide Exchange Factor 20%
• Mammalian Target of Rapamycin Complex 1 20%
• Mitochondrial Biogenesis 20%

Biochemistry, Genetics and Molecular Biology

• Astrocyte 100%
• Genetics 40%
• Adenosine Triphosphate 40%
• Fibroblast 40%
• Oxidative Stress 20%
• Homeostasis 20%
• Cancer Cell 20%
• Enzyme Activity 20%
• Protein Biosynthesis 20%
• Electron Transport Chain 20%
• Guanine Nucleotide Exchange Factor 20%
• Oxidative Phosphorylation 20%
• AMP-activated Protein Kinase 20%
• Erethism 20%
• Initiation Factor 20%
• Mammalian Target of Rapamycin Complex 1 20%
• Mitochondrial Biogenesis 20%