The Endosteum Region Keeps Human Leukemic Stem Cells Alive

Tsvee Lapidot; Polina Goichberg; Kfir Lapid; Abraham Avigdor; Orit Kollet

doi:10.1016/j.stem.2007.10.013

The Endosteum Region Keeps Human Leukemic Stem Cells Alive

Tsvee Lapidot^*, Polina Goichberg, Kfir Lapid, Abraham Avigdor, Orit Kollet

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

6 Scopus citations

Abstract

Only a subset of hierarchically arranged, primitive human AML progenitor cells can initiate the disease in transplanted immune-deficient mice. A publication in Nature Biotechnology by Ishikawa et al. (2007) describes a new animal model to study chemotherapy-resistant, quiescent human AML CD34⁺CD38^- stem cells, which are retained in the endosteum region.

Original language	English
Pages (from-to)	483-484
Number of pages	2
Journal	Cell Stem Cell
Volume	1
Issue number	5
DOIs	https://doi.org/10.1016/j.stem.2007.10.013
State	Published - 15 Nov 2007
Externally published	Yes

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10.1016/j.stem.2007.10.013

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title = "The Endosteum Region Keeps Human Leukemic Stem Cells Alive",

abstract = "Only a subset of hierarchically arranged, primitive human AML progenitor cells can initiate the disease in transplanted immune-deficient mice. A publication in Nature Biotechnology by Ishikawa et al. (2007) describes a new animal model to study chemotherapy-resistant, quiescent human AML CD34+CD38- stem cells, which are retained in the endosteum region.",

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AU - Goichberg, Polina

AU - Lapid, Kfir

AU - Avigdor, Abraham

AU - Kollet, Orit

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AB - Only a subset of hierarchically arranged, primitive human AML progenitor cells can initiate the disease in transplanted immune-deficient mice. A publication in Nature Biotechnology by Ishikawa et al. (2007) describes a new animal model to study chemotherapy-resistant, quiescent human AML CD34+CD38- stem cells, which are retained in the endosteum region.

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The Endosteum Region Keeps Human Leukemic Stem Cells Alive

Abstract

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