The Endosteum Region Keeps Human Leukemic Stem Cells Alive

Tsvee Lapidot*, Polina Goichberg, Kfir Lapid, Abraham Avigdor, Orit Kollet

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review


Only a subset of hierarchically arranged, primitive human AML progenitor cells can initiate the disease in transplanted immune-deficient mice. A publication in Nature Biotechnology by Ishikawa et al. (2007) describes a new animal model to study chemotherapy-resistant, quiescent human AML CD34+CD38- stem cells, which are retained in the endosteum region.

Original languageEnglish
Pages (from-to)483-484
Number of pages2
JournalCell Stem Cell
Issue number5
StatePublished - 15 Nov 2007
Externally publishedYes


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