The emerging role of SMPD1 mutations in Parkinson's disease: Implications for future studies

Ziv Gan-Or*, Avi Orr-Urtreger, Roy N. Alcalay, Susan Bressman, Nir Giladi, Guy A. Rouleau

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review

39 Scopus citations

Abstract

Recently, an additional study confirmed the association between SMPD1 mutations and Parkinson's disease (PD). While the first study on SMPD1 and PD suggested that only one SMPD1 mutations is responsible for the association to PD, the recent study argued that all SMPD1 mutations may be associated with an increased risk for PD. Since SMPD1 mutations are being routinely screened in some populations with high carrier frequencies, and since it will be further screened in additional PD populations, it is important to better define the association between SMPD1 and PD. We reanalyzed the data from the recent and previous papers, and we show that the association between SMPD1 and PD is indeed not driven by only one mutation, but it is also not driven by all SMPD1 mutations. In the Ashkenazi-Jewish population, the p.fs330P (OR = 3.03, p = 0.0026) and p.L302P (OR = 9.62, p < 0.0001) are associated with PD, and the p.R496L mutation is not (OR = 0.84, p = 0.71), and similar observation was noted in the Chinese population. Thus, we conclude that similar to the GBA gene where different mutations have differential effects, SMPD1 mutations also have a differential effects on the risk for PD. Future studies should therefore examine the association by mutation and not by accumulative risk of all mutations.

Original languageEnglish
Article number2741
Pages (from-to)1294-1295
Number of pages2
JournalParkinsonism and Related Disorders
Volume21
Issue number10
DOIs
StatePublished - 1 Oct 2015

Funding

FundersFunder number
Chief Scientist Israel Ministry of Health3-4893
Empire State Clinical Research Training Program
Legacy Heritage Biomedical Science Partnership Program of the Israel Science Foundation1922/08
Marcled Foundation
NIH-NINDSNS073836
National Institutes of Health
National Institute of Neurological Disorders and StrokeK02NS073836
Michael J. Fox Foundation for Parkinson's Research
Esther B. Kahn Charitable Foundation
Canadian Institutes of Health Research

    Keywords

    • GBA
    • Genetics
    • Parkinson's disease
    • SMPD1

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