The elution of antibodies from viable murine tumor cells

Rachel Ehrlich*, Isaac P. Witz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Several low pH buffers were used in order to dissociate radioiodinated antibodies from sensitized living tumor cells. Three buffers were further tested for their dissociation abilities under different conditions of time and temperature, and for their influence on the eluted antibodies. The cytotoxicity mediated by these low pH buffers was also determined by viability assays. Optimal results were obtained with 0.1 M citrate buffer at pH 3.5.

Original languageEnglish
Pages (from-to)345-353
Number of pages9
JournalJournal of Immunological Methods
Issue number4
StatePublished - 24 Apr 1979


FundersFunder number
National Cancer Institute


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