The efficacy of omeprazole-based short-term triple therapy in Helicobacter pylori-positive older patients with dyspepsia

Menachem Moshkowitz*, Shlomo Brill, Fred M. Konikoff, Shimon Reif, Nadir Arber, Zamir Halpern

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


OBJECTIVE: To evaluate the efficacy of 1-week triple therapy with omeprazole, clarithromycin, and tinidazole (OCT) in Helicobacter pylori- positive older patients with dyspepsia. DESIGN: A prospective, nonrandomized therapeutic study. SETTING: The primary care and referral center of a gastroenterological outpatient clinic at a central university hospital serving an urban population (>1 million) in Israel. PARTICIPANTS: The study group consisted of 134 patients (71 men, and 63 women) more than 60 years old who were referred for evaluation of symptoms of dyspepsia and were endoscopically diagnosed as H. pylori positive. The patients were divided into two groups: those who received their first course of anti-H. Pylori therapy during this study (Group 1) and those who had previously received standard metronidazole and bismuth combination therapies that failed to eradicate the H. pylori (Group 2). MEASUREMENTS: All the patients underwent upper gastrointestinal endoscopy, and H. pylori infection was confirmed by a rapid urease test (CUTest) and/or histological staining. Therapeutic efficacy was assessed by a 13C-urea breath test 4 weeks after completion of treatment. RESULTS: The mean age of the study population was 68.8 years (range 60-87). There were 112 patients in Group 1 and 22 patients in Group 2. Endoscopic findings were: gastritis (in 46), gastric ulcer (8), duodenal ulcer (52), and duodenitis (28). The H. pylori eradication rate was significantly higher in Group 1 patients (104/112, 92.9%) than in patients of Group 2 (15/22, 68.2%). There was no difference in the eradication rate in relation to gender, endoscopic diagnosis, more advanced age, place of birth, or smoking habits. The compliance in both groups was equally good, and no major side effects were recorded. CONCLUSIONS: A 1-week OCT triple therapy is well tolerated and effective as first line therapy for H. pylori among older people. It is less effective in patients previously treated.

Original languageEnglish
Pages (from-to)720-722
Number of pages3
JournalJournal of the American Geriatrics Society
Issue number6
StatePublished - Jun 1999


  • Clarithromycin
  • Helicobacter pylori
  • Older people
  • Omeprazole


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