The efficacy and safety of early supplementation of iron polymaltose complex in preterm infants

Shmuel Arnon*, Yakov Shiff, Ita Litmanovitz, Rivka H. Regev, Sofia Bauer, Ruth Shainkin-Kestenbaum, Yoram Bental, Tzipora Dolfin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this study was to examine the efficacy and safety of early nonionic iron supplementation in preterm infants. Infants with gestational age ≤ 32 weeks who were fed enriched human milk were assigned concurrently to receive 5 mg/kg/d enteral iron polymaltose complex (IPC) at 2 or 4 weeks of age. The levels of hemoglobin, reticulocytes, serum iron, ferritin, and soluble transferrin receptor were recorded at 2, 4, and 8 weeks of age. The incidence of morbidities associated with prematurity and the need for red blood cell transfusions (RBCTs) were recorded. The 2-week group (n = 32) had a better iron status than the 4-week group (n = 36) at 4 weeks and at 8 weeks of age. The incidence of morbidities associated with prematurity was not different among the groups (p = 0.26). RBCT was required in one infants of the 2-week group and in 10 infants in the 4-week group (p = 0.045). The number needed to treat to prevent one RBCT was five. Supplementation of 5 mg/kg/d enterai IPC to preterm infants fed enriched human milk as early as 2 weeks of age was more beneficial to iron status than at 4 weeks of age, and was associated with decreased need for RBCTs and no increase in the incidence of morbidities associated with prematurity.

Original languageEnglish
Pages (from-to)95-99
Number of pages5
JournalAmerican Journal of Perinatology
Volume24
Issue number2
DOIs
StatePublished - Feb 2007

Keywords

  • Iron polymaltose complex
  • Iron supplementation
  • Morbidities associated with prematurity
  • Preterm infants

Fingerprint

Dive into the research topics of 'The efficacy and safety of early supplementation of iron polymaltose complex in preterm infants'. Together they form a unique fingerprint.

Cite this