@article{7aea2fbbb56f45d380ad22f3c8b1380d,
title = "The effects of succinylacetone (4,6-dioxoheptanoic acid) on δ-aminolevulinate synthase activity and the content of heme in monolayers of chick embryo liver cells",
abstract = "Succinylacetone was shown to inhibit aminolevulinate dehydratase (5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing), EC 4.2.1.24) to reduce cellular heme and porphyrins and to induce δ-aminolevulinate synthase (succinyl-CoA:glycine C-succinyltransferase (decarboxylating), EC 2.3.1.37) in monolayers of chick embryo liver cells. Marked synergistic effects on δ-aminolevulinate synthase activity were obtained by combining succinylacetone with levulinate and porphyrogenic drugs. The time course of δ-aminolevulinate synthase activity showed a delayed synergistic response.",
keywords = "(Chick embryo liver cell), Aminolevulinate synthase, Heme content, Porphobilinogen, Succinylacetone",
author = "Nili Schoenfeld and Yehudit Greenblat and Orit Epstein and Abraham Atsmon",
note = "Funding Information: This work has been supported by a grant from the Offer Fund, Sackler School of Medicine, University of Tel Aviv, Ramat Aviv, Israel.",
year = "1982",
month = dec,
day = "30",
doi = "10.1016/0167-4889(82)90096-9",
language = "אנגלית",
volume = "721",
pages = "408--417",
journal = "BBA - Molecular Cell Research",
issn = "0167-4889",
publisher = "Elsevier B.V.",
number = "4",
}