The effects of succinylacetone (4,6-dioxoheptanoic acid) on δ-aminolevulinate synthase activity and the content of heme in monolayers of chick embryo liver cells

Nili Schoenfeld, Yehudit Greenblat, Orit Epstein, Abraham Atsmon

Research output: Contribution to journalArticlepeer-review

Abstract

Succinylacetone was shown to inhibit aminolevulinate dehydratase (5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing), EC 4.2.1.24) to reduce cellular heme and porphyrins and to induce δ-aminolevulinate synthase (succinyl-CoA:glycine C-succinyltransferase (decarboxylating), EC 2.3.1.37) in monolayers of chick embryo liver cells. Marked synergistic effects on δ-aminolevulinate synthase activity were obtained by combining succinylacetone with levulinate and porphyrogenic drugs. The time course of δ-aminolevulinate synthase activity showed a delayed synergistic response.

Original languageEnglish
Pages (from-to)408-417
Number of pages10
JournalBBA - Molecular Cell Research
Volume721
Issue number4
DOIs
StatePublished - 30 Dec 1982

Keywords

  • (Chick embryo liver cell)
  • Aminolevulinate synthase
  • Heme content
  • Porphobilinogen
  • Succinylacetone

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