The effects of smoking on acoustic prepulse inhibition in healthy men and women

V. Della Casa, I. Höfer, I. Weiner, J. Feldon*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

Acoustic prepulse inhibition (PPI) refers to the reduction of the startle reflex to an intense stimulus if it is preceded by a weak stimulus. Nicotine and smoking have been reported to enhance PPI in rats and in healthy men, respectively. We studied the influence of smoking on PPI in healthy men and women, comparing non-smokers, deprived smokers, and smokers smoking during the test session after deprivation or after ad libitum smoking. Smoking during the session enhanced PPI, without affecting startle reaction or habituation over time. In addition, the effect of smoking on PPI was gender dependent. In men, ad libitum smoking enhanced PPI compared with non- smokers, while, in women, deprivation reduced PPI and smoking restored PPI to the level of non-smokers.

Original languageEnglish
Pages (from-to)362-368
Number of pages7
JournalPsychopharmacology
Volume137
Issue number4
DOIs
StatePublished - 1998

Funding

FundersFunder number
Federation of the Swiss Cigarette Industry

    Keywords

    • Gating
    • Gender
    • Human
    • Nicotine
    • Prepulse inhibition
    • Smoking
    • Startle

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