@article{0e812eb60f1e4246b5df69e8613c5783,
title = "The effects of radiofrequency lesion or transection of the fimbria- fornix on latent inhibition in the rat",
abstract = "Latent inhibition consists of a decrement in conditioning to a stimulus as a result of its prior non-reinforced pre-exposure. Based on evidence pointing to the involvement of the hippocampus and the nucleus accumbens in latent inhibition disruption, it has been proposed that latent inhibition depends on the integrity of the subicular input to the nucleus accumbens. Since fibers originating in the subiculum and destined for the nucleus accumbens run through the fimbria-fornix, we assessed the effects of radiofrequency lesion or transection of the fimbria-fornix, on latent inhibition. The effectiveness of both lesions was demonstrated by the total disappearance of acetylcholinesterase staining in the hippocampus and of retrogradely labeled cells in the hippocampus/subiculum following the injection of the retrograde tracer biotin-dextran amine into the shell subregion of the nucleus accumbens. Likewise, in accord with previously documented behavioral effects of lesions to the hippocampus and related structures, both lesions increased spontaneous activity and disrupted performance in Morris water maze, and the radiofrequency lesion facilitated the acquisition of two-way active avoidance. In spite of the above, latent inhibition remained unaffected by both fimbria-fornix lesions, indicating that the critical projections subserving latent inhibition are not those traversing the fimbria-fornix from the hippocampus/subiculum to the nucleus accumbens. The implications of these results for the neural circuitry of latent inhibition and the latent inhibition model of schizophrenia are discussed.",
keywords = "Fimbria-fornix lesion, Latent inhibition, Morris water maze, Schizophrenia, Two-way active avoidance",
author = "B. Pouzet and Veenman, {C. L.} and Yee, {B. K.} and J. Feldon and I. Weiner",
note = "Funding Information: This work was supported by grants from the Swiss National Science Foundation and the Swiss Federal Institute of Technology, Zurich. The authors thank the animal facility team of Dr Allmann for their care of the animals, Ms Liz Weber for her histological preparations and Ms Bonnie Strehler for her assistance with manuscript preparation.",
year = "1999",
month = jul,
doi = "10.1016/S0306-4522(98)00691-5",
language = "אנגלית",
volume = "91",
pages = "1355--1368",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "Elsevier Ltd.",
number = "4",
}