The effects of prenatal chlordiazepoxide administration on avoidance behavior and benzodiazepine receptor density in adult albino rats

N. Avnimelech-Gigus, J. Feldon, Z. Tanne, M. Gavish

Research output: Contribution to journalArticlepeer-review

Abstract

Adult male and female offspring of rats injected daily with 10 mg/kg chlordiazepoxide during their pregnancy exhibited a facilitated acquisition of a two-way active avoidance response. Benzodiazepine receptor assays carried out on cortex and cerebral samples taken from experimental and control female rats showed a significant decrease in the density of benzodiazepine receptors, without changes in receptor affinity.

Original languageEnglish
Pages (from-to)185-188
Number of pages4
JournalEuropean Journal of Pharmacology
Volume129
Issue number1-2
DOIs
StatePublished - 23 Sep 1986

Keywords

  • (Rat)
  • Avoidance behavior
  • Benzodiazepine receptors
  • Chlordiazepoxide
  • Prenatal administration

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