The effects of perioperative pain management techniques on food consumption and body weight after laparotomy in rats

Yehuda Shavit, Gila Fish, Gilly Wolf, Eduard Mayburd, Ylia Meerson, Raz Yirmiya, Benzion Beilin

Research output: Contribution to journalArticlepeer-review

Abstract

We examined the effects of two perioperative pain management techniques on recovery after laparotomy, as assessed by body weight (BW) and food consumption (FC). All rats received a preoperative intrathecal mixture of morphine plus bupivacaine combined with one of two treatments: (a) injection of slow-release morphine at the end of the surgery or (b) an antiinflammatory drug, interleukin-1 receptor antagonist (IL-1ra), combined with the preoperative mixture. Laparotomy significantly decreased FC and BW. Both analgesic treatments resulted in a faster recovery of FC and BW. This beneficial effect was more pronounced in the group receiving preoperative analgesics combined with IL-1ra.

Original languageEnglish
Pages (from-to)1112-1116
Number of pages5
JournalAnesthesia and Analgesia
Volume101
Issue number4
DOIs
StatePublished - Oct 2005

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