The effects of parental behaviors, attitudes, and drug-use as perceived by adolescents on the latter's attitudes toward and intent to use psychoactive substances were studied. Perceived parental rejection, acceptance, and attitudes significantly differentiated between adolescents who reported favorable attitudes toward and high intent to use substances and those who expressed less favorable attitudes. On most parameters, the father's influence was significant, whereas the effect of the mother did not reach significance. Positive and significant relationships were also found between perceived parental rejection, acceptance, and attitudes and adolescent attitudes and intent to use psychoactive substances. No relationships were found between controlling parental behavior and adolescent attitudes and intent to use psychoactive substances. The role of the parents, as well as implications of the findings for prevention are discussed.