TY - JOUR
T1 - The effects of leucovorin (folinic acid) on methotrexate therapy in rheumatoid arthritis patients
AU - Tishler, Moshe
AU - Caspi, Dan
AU - Fishel, Beno
AU - Yaron, Michael
PY - 1988/7
Y1 - 1988/7
N2 - High‐dose leucovorin (folinic acid) supplementation was tested in a prospective, unblinded manner for 4 weeks in 7 rheumatoid arthritis patients who were being treated successfully with low‐dose methotrexate (MTX). Nausea caused by MTX disappeared; however, the underlying rheumatic disease worsened in all patients. Subjective clinical assessment, Ritchie articular index, grip strength, erythrocyte sedimentation rate, and levels of C‐reactive protein showed statistically significant deterioration. All these parameters improved after the leucovorin was stopped. This is the first direct clinical evidence implying folate antagonism in the action of low‐dose MTX therapy in rheumatoid arthritis patients.
AB - High‐dose leucovorin (folinic acid) supplementation was tested in a prospective, unblinded manner for 4 weeks in 7 rheumatoid arthritis patients who were being treated successfully with low‐dose methotrexate (MTX). Nausea caused by MTX disappeared; however, the underlying rheumatic disease worsened in all patients. Subjective clinical assessment, Ritchie articular index, grip strength, erythrocyte sedimentation rate, and levels of C‐reactive protein showed statistically significant deterioration. All these parameters improved after the leucovorin was stopped. This is the first direct clinical evidence implying folate antagonism in the action of low‐dose MTX therapy in rheumatoid arthritis patients.
UR - http://www.scopus.com/inward/record.url?scp=0023785897&partnerID=8YFLogxK
U2 - 10.1002/art.1780310712
DO - 10.1002/art.1780310712
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AN - SCOPUS:0023785897
SN - 0004-3591
VL - 31
SP - 906
EP - 908
JO - Arthritis and Rheumatology
JF - Arthritis and Rheumatology
IS - 7
ER -