The effects of hornet venom sac extract on the electrical activity of the cat brain

J. Ishay; Y. Lass; D. Ben-Schachar; S. Gitter; U. Sandbank

doi:10.1016/0041-0101(74)90240-2

The effects of hornet venom sac extract on the electrical activity of the cat brain

J. Ishay^*, Y. Lass, D. Ben-Schachar, S. Gitter, U. Sandbank

^*Corresponding author for this work

Physiology Pharmacology

Research output: Contribution to journal › Article › peer-review

Abstract

A method for testing minute quantities of extracts of hornet venom sacs by injection into the vertebral artery of cats is described. Neurotoxic effects of venom sacs manifested by isoelectric EEG and by depression of respiratory centre, appeared prior to cardiovascular manifestations. Injection into the carotid artery necessitated 100 times large amounts of venom and a longer time elapsed before results similar to those after intravertebral injection were obtained. The cardiovascular manifestations preceded the cerebral effect using intracarotid injection. The active fraction seems to be proteinaceous, has antigenic properties and does not cross a dialysis membrane. Incubation of venom with antivenin serum prepared by immunization of a goat caused inactivation of the neurotoxic and hemolytic effects of the venom sac extract.

Original language	English
Pages (from-to)	159-164
Number of pages	6
Journal	Toxicon
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/0041-0101(74)90240-2
State	Published - Mar 1974

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10.1016/0041-0101(74)90240-2

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abstract = "A method for testing minute quantities of extracts of hornet venom sacs by injection into the vertebral artery of cats is described. Neurotoxic effects of venom sacs manifested by isoelectric EEG and by depression of respiratory centre, appeared prior to cardiovascular manifestations. Injection into the carotid artery necessitated 100 times large amounts of venom and a longer time elapsed before results similar to those after intravertebral injection were obtained. The cardiovascular manifestations preceded the cerebral effect using intracarotid injection. The active fraction seems to be proteinaceous, has antigenic properties and does not cross a dialysis membrane. Incubation of venom with antivenin serum prepared by immunization of a goat caused inactivation of the neurotoxic and hemolytic effects of the venom sac extract.",

author = "J. Ishay and Y. Lass and D. Ben-Schachar and S. Gitter and U. Sandbank",

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AB - A method for testing minute quantities of extracts of hornet venom sacs by injection into the vertebral artery of cats is described. Neurotoxic effects of venom sacs manifested by isoelectric EEG and by depression of respiratory centre, appeared prior to cardiovascular manifestations. Injection into the carotid artery necessitated 100 times large amounts of venom and a longer time elapsed before results similar to those after intravertebral injection were obtained. The cardiovascular manifestations preceded the cerebral effect using intracarotid injection. The active fraction seems to be proteinaceous, has antigenic properties and does not cross a dialysis membrane. Incubation of venom with antivenin serum prepared by immunization of a goat caused inactivation of the neurotoxic and hemolytic effects of the venom sac extract.

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The effects of hornet venom sac extract on the electrical activity of the cat brain

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