TY - JOUR
T1 - The effects of hormone replacement therapy in normal postmenopausal women
T2 - Measurements of Doppler-derived parameters of aortic flow
AU - Pines, Amos
AU - Fisman, Enrique Z.
AU - Levo, Yoram
AU - Averbuch, Mordechai
AU - Lidor, Arie
AU - Drory, Yaacov
AU - Finkelstein, Ariel
AU - Hetman-Peri, Miriam
AU - Moshkowitz, Menachem
AU - Ben-Ari, Efraim
AU - Ayalon, Daniel
N1 - Funding Information:
From the Department of Medicine T" and the Timsit Institute for Reproductive Endocrinology,' Ichilov Hospital, Tel Aviv Sourasky Medical Center, the Cardiac Rehabilitation Institute, Sheba Medical Center, Tel Hashomer,' affiliated with the Sackler Faculty of Medicine, Tel Aviv University, and the Menopause Clinic of the Maccabi Medical Care and Health Fund, Tel Aviv.d This study was supported {n part by Ciba-Geigy, Basel, Switzerland. Received for publication September 5, 1990; revised October 25, 1990; accepted November 6, 1990. Reprint requests: Amos Pines, MD, Department of Medicine T, lchilov Hospital, 6 Weizman St., Tel-Aviv, Israel 64239. 6/1/26586
PY - 1991
Y1 - 1991
N2 - In this study the effects of hormone replacement therapy on cardiac function in healthy postmenopausal women were evaluated by Doppler echocardiography that was performed before (T1) and 2.5 months after the initiation of hormone replacement therapy (T2) in the peak estrogenic phase. The following parameters of aortic flow were measured: peak flow velocity, acceleration time, and ejection time. Additional parameters were calculated: flow velocity integral and mean acceleration. The study group included 24 postmenopausal women aged 43 to 60 years (mean 51.6 years). The control group consisted of 19 postmenopausal women aged 46 to 60 years (mean 53.5 years) who were not receiving hormone replacement therapy and who underwent the same evaluation. There were no changes in all Doppler parameters between T1 and T2 in the control group. However, in the study group there were significant increases in peak flow velocity (108.3 ± 16.7 cm/sec at T1 vs 123 ± 20.7 cm/sec at T2; p = 0.002), flow velocity integral (17.7 ± 3.9 vs 21.5 ± 4.7 cm; p = 0.0003), mean acceleration (11.5 ± 1.9 vs 13.1 ± 2.6 m/sec/sec; p = 0.001), and ejection time (324 ± 37.6 vs 348.8 ± 40.7 msec; p = 0.002). There was no change in acceleration time (94.8 ± 6.6 vs 95 ± 10.9 msec). These results demonstrate that estrogens increase both stroke volume and flow acceleration. The latter probably reflects a combination of enhanced inotropism and vasodilatation. We assume that the cardioprotective effect of hormone replacement therapy in postmenopausal women may be due not only to changes in lipid profile but also to direct effects of estrogens on central and peripheral hemodynamic parameters.
AB - In this study the effects of hormone replacement therapy on cardiac function in healthy postmenopausal women were evaluated by Doppler echocardiography that was performed before (T1) and 2.5 months after the initiation of hormone replacement therapy (T2) in the peak estrogenic phase. The following parameters of aortic flow were measured: peak flow velocity, acceleration time, and ejection time. Additional parameters were calculated: flow velocity integral and mean acceleration. The study group included 24 postmenopausal women aged 43 to 60 years (mean 51.6 years). The control group consisted of 19 postmenopausal women aged 46 to 60 years (mean 53.5 years) who were not receiving hormone replacement therapy and who underwent the same evaluation. There were no changes in all Doppler parameters between T1 and T2 in the control group. However, in the study group there were significant increases in peak flow velocity (108.3 ± 16.7 cm/sec at T1 vs 123 ± 20.7 cm/sec at T2; p = 0.002), flow velocity integral (17.7 ± 3.9 vs 21.5 ± 4.7 cm; p = 0.0003), mean acceleration (11.5 ± 1.9 vs 13.1 ± 2.6 m/sec/sec; p = 0.001), and ejection time (324 ± 37.6 vs 348.8 ± 40.7 msec; p = 0.002). There was no change in acceleration time (94.8 ± 6.6 vs 95 ± 10.9 msec). These results demonstrate that estrogens increase both stroke volume and flow acceleration. The latter probably reflects a combination of enhanced inotropism and vasodilatation. We assume that the cardioprotective effect of hormone replacement therapy in postmenopausal women may be due not only to changes in lipid profile but also to direct effects of estrogens on central and peripheral hemodynamic parameters.
KW - Doppler echocardiography
KW - Menopause
KW - aortic blood flow
KW - hormone replacement therapy
UR - http://www.scopus.com/inward/record.url?scp=0026069110&partnerID=8YFLogxK
U2 - 10.1016/0002-9378(91)90520-2
DO - 10.1016/0002-9378(91)90520-2
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AN - SCOPUS:0026069110
SN - 0002-9378
VL - 164
SP - 806
EP - 812
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 3
ER -