The effects of flumazenil on the process of recovery from halothane anaesthesia

E. Geller, A. Weinbrum, B. Schiff, Z. Speiser, Y. Nevo, P. Halpern, S. Cohen

Research output: Contribution to journalArticlepeer-review

Abstract

Cheng and Brunner recently proposed a GABA hypothesis for the mechanism of action of anaesthetic agents. They presented evidence suggesting that halothane produces a state of anaesthesia by modifying CNS GABA-ergic transmission. Benzodiazepines (BZ), on the other hand, are known to modulate GABA-ergic transmission by binding to the benzodiazepine receptors (BZR). The following studies were designed in order to test the hypothesis that the specific BZR antagonist flumazenil interacts with halothane anaesthesia to hasten recovery.

Original languageEnglish
Pages (from-to)151-153
Number of pages3
JournalEuropean Journal of Anaesthesiology
Volume5
Issue numberSUPPL. 2
StatePublished - 1988
Externally publishedYes

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