The effects of exercise on body weight and circulating leptin in premature infants

Alon Eliakim, Tzipora Dolfin, Eli Weiss, Ruth Shainkin-Kestenbaum, Monica Lis, Dan Nemet

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To assess the effect of daily movements on weight gain, serum leptin, and insulin-like growth factor I (IGF-I) in premature infants. Study Design: Twenty very-low-birth-weight premature infants were matched and randomized to a daily movement (n = 10) and control groups (n = 10). Daily movement consised of passive range of motion with gentle compression of both the upper and lower extremities 5 days per week for 4 weeks. Results: Daily movements led to a significant increase in weight gain (784 ± 51 vs 608 ± 26 g in movements and controls, respectively, p<0.02), and to a significant increase in leptin (0.60 ± 0.19 vs 0.13 ± 0.06 ng/ml in movements and controls, respectively, p<0.05). Changes in body weight correlated with changes in serum lepin (r=0.48, p<0.03). IGF - I also increased following daily movements (18.8 ± 4.1 vs 9.2 ± 4.1 ng/ml in movements and controls, respectively); however, this increase was not statistically significant. Conclusion: A relatively brief range of motion daily movement intervention was associated with greater weight gain and increased leptin levels in very-low-birth-weight premature infants. This may suggest that at least part of the daily movements associated with increase in body weight resulted from an increase in adipose tissue.

Original languageEnglish
Pages (from-to)550-554
Number of pages5
JournalJournal of Perinatology
Volume22
Issue number7
DOIs
StatePublished - 2002

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