The effects of amphetamine on a multitrial partial reinforcement extinction effect (PREE) in an operant chamber

J. Feldon, I. Weiner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Two experiments investigated the effects of d-amphetamine (1 mg/kg) on the partial reinforcement extinction effect (PREE) in an operant chamber using a discrete multitrial procedure. Experiment 1 used a random 50% partial reinforcement (PRF) schedule. Experiment 2 used two 40% PRF schedules: one schedule maximized the number of nonreinforced trials preceding any given reinforced trial (maximum N-length of four) and the second maximized the number of N-R transitions (N-length of one). In both experiments, the continuously reinforced (CRF) animals received a reward on every trial. The PREE, i.e., increased resistance to extinction of PRF as compared to CRF animals, was obtained in the random 50% PRF and the schedule maximizing N-length in both the placebo and amphetamine-treated animals. Both drug and no-drug animals failed to exhibit PREE on the schedule maximizing N-R transitions. These results show that on a PRF schedule with short intertrial intervals, amphetamine-treated animals are not impaired in their capacity to learn sequences of events and to associate the outcomes of preceding trials with subsequent consequences.

Original languageEnglish
Pages (from-to)65-69
Number of pages5
JournalPharmacology Biochemistry and Behavior
Volume32
Issue number1
DOIs
StatePublished - Jan 1989

Keywords

  • Continuous reinforcement
  • Extinction
  • Partial reinforcement
  • Rat
  • d-Amphetamine

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