TY - JOUR
T1 - The effects of amphetamine on a multitrial partial reinforcement extinction effect (PREE) in a runway
AU - Feldon, J.
AU - Bercovitz, H.
AU - Weiner, I.
N1 - Funding Information:
This study was supported by a grant from the Israeli Ministry of Health-Chief Scientists's Office to J. Feldon and I. Weiner. We thank Ms. Paula van der Werff for excellent typing of the manuscript.
PY - 1989/1
Y1 - 1989/1
N2 - Three experiments examined the effects of d-amphetamine (1 mg/kg) administration on the partial reinforcement extinction effect (PREE) using a multitrial procedure. Two groups of rats were trained to run in a straight alley. The continuously reinforced (CRF) group received food reward on every trial. The partially reinforced (PRF) group was rewarded on a quasi-random 50% schedule. All animals were then tested in extinction. Experiments 1 and 2 used 6 trials/day with an intertrial interval (ITI) of 5 min. In Experiment 1 the drug was administered only during acquisition, whereas in Experiment 2 it was administered throughout acquisition and extinction. Experiment 3 used 3 trials/day with a 20 min ITI. The drug was administered throughout acquisition and extinction. In all three experiments, amphetamine-treated animals showed a normal PREE, i.e., increased resistance to extinction in PRF as compared to CRF animals. These results stand in marked contrast to the amphetamine-induced abolition of the PREE with 1 trial/day procedure.
AB - Three experiments examined the effects of d-amphetamine (1 mg/kg) administration on the partial reinforcement extinction effect (PREE) using a multitrial procedure. Two groups of rats were trained to run in a straight alley. The continuously reinforced (CRF) group received food reward on every trial. The partially reinforced (PRF) group was rewarded on a quasi-random 50% schedule. All animals were then tested in extinction. Experiments 1 and 2 used 6 trials/day with an intertrial interval (ITI) of 5 min. In Experiment 1 the drug was administered only during acquisition, whereas in Experiment 2 it was administered throughout acquisition and extinction. Experiment 3 used 3 trials/day with a 20 min ITI. The drug was administered throughout acquisition and extinction. In all three experiments, amphetamine-treated animals showed a normal PREE, i.e., increased resistance to extinction in PRF as compared to CRF animals. These results stand in marked contrast to the amphetamine-induced abolition of the PREE with 1 trial/day procedure.
KW - Continuous reinforcement
KW - Intertrial interval
KW - Partial reinforcement
KW - Rat
KW - Resistance to extinction
KW - d-Amphetamine
UR - http://www.scopus.com/inward/record.url?scp=0024583794&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(89)90210-4
DO - 10.1016/0091-3057(89)90210-4
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AN - SCOPUS:0024583794
SN - 0091-3057
VL - 32
SP - 55
EP - 63
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
IS - 1
ER -