The Effect of Vincristine on Haemoglobin Synthesis

Isaac Ben‐Bassat, Miriam Mozel, Ziva Mark, Bracha Ramot

Research output: Contribution to journalArticlepeer-review

Abstract

Vincristine in a concentration of 0.5 and 4 times 10−5 M causes a decrease of 16 % and 73 % respectively, in the synthesis of globin by peripheral blood reticulocytes. At the higher drug concentration the α/β ratio is significantly lower than the normal ratio of unity and is 0.83 ± 0.09. These effects of vincristine are probably related to the ability of the vinca alkaloids to bind to ribosomes and their subunits.

Original languageEnglish
Pages (from-to)304-308
Number of pages5
JournalScandinavian Journal of Haematology
Volume19
Issue number3
DOIs
StatePublished - Sep 1977

Keywords

  • haemoglobin synthesis
  • vincristine

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