The Effect of Vincristine on Haemoglobin Synthesis

Isaac Ben‐Bassat; Miriam Mozel; Ziva Mark; Bracha Ramot

doi:10.1111/j.1600-0609.1977.tb02110.x

The Effect of Vincristine on Haemoglobin Synthesis

Isaac Ben‐Bassat^*, Miriam Mozel, Ziva Mark, Bracha Ramot

^*Corresponding author for this work

Clinical Departments

Research output: Contribution to journal › Article › peer-review

Abstract

Vincristine in a concentration of 0.5 and 4 times 10⁻⁵ M causes a decrease of 16 % and 73 % respectively, in the synthesis of globin by peripheral blood reticulocytes. At the higher drug concentration the α/β ratio is significantly lower than the normal ratio of unity and is 0.83 ± 0.09. These effects of vincristine are probably related to the ability of the vinca alkaloids to bind to ribosomes and their subunits.

Original language	English
Pages (from-to)	304-308
Number of pages	5
Journal	Scandinavian Journal of Haematology
Volume	19
Issue number	3
DOIs	https://doi.org/10.1111/j.1600-0609.1977.tb02110.x
State	Published - Sep 1977

Keywords

haemoglobin synthesis
vincristine

Access to Document

10.1111/j.1600-0609.1977.tb02110.x

Cite this

@article{3633c64ba5414859bee76caa00f86548,

title = "The Effect of Vincristine on Haemoglobin Synthesis",

abstract = "Vincristine in a concentration of 0.5 and 4 times 10−5 M causes a decrease of 16 % and 73 % respectively, in the synthesis of globin by peripheral blood reticulocytes. At the higher drug concentration the α/β ratio is significantly lower than the normal ratio of unity and is 0.83 ± 0.09. These effects of vincristine are probably related to the ability of the vinca alkaloids to bind to ribosomes and their subunits.",

keywords = "haemoglobin synthesis, vincristine",

author = "Isaac Ben‐Bassat and Miriam Mozel and Ziva Mark and Bracha Ramot",

year = "1977",

month = sep,

doi = "10.1111/j.1600-0609.1977.tb02110.x",

language = "אנגלית",

volume = "19",

pages = "304--308",

journal = "Scandinavian Journal of Haematology",

issn = "0036-553X",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "3",

}

TY - JOUR

T1 - The Effect of Vincristine on Haemoglobin Synthesis

AU - Ben‐Bassat, Isaac

AU - Mozel, Miriam

AU - Mark, Ziva

AU - Ramot, Bracha

PY - 1977/9

Y1 - 1977/9

N2 - Vincristine in a concentration of 0.5 and 4 times 10−5 M causes a decrease of 16 % and 73 % respectively, in the synthesis of globin by peripheral blood reticulocytes. At the higher drug concentration the α/β ratio is significantly lower than the normal ratio of unity and is 0.83 ± 0.09. These effects of vincristine are probably related to the ability of the vinca alkaloids to bind to ribosomes and their subunits.

AB - Vincristine in a concentration of 0.5 and 4 times 10−5 M causes a decrease of 16 % and 73 % respectively, in the synthesis of globin by peripheral blood reticulocytes. At the higher drug concentration the α/β ratio is significantly lower than the normal ratio of unity and is 0.83 ± 0.09. These effects of vincristine are probably related to the ability of the vinca alkaloids to bind to ribosomes and their subunits.

KW - haemoglobin synthesis

KW - vincristine

UR - http://www.scopus.com/inward/record.url?scp=0017701021&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0609.1977.tb02110.x

DO - 10.1111/j.1600-0609.1977.tb02110.x

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 905769

AN - SCOPUS:0017701021

SN - 0036-553X

VL - 19

SP - 304

EP - 308

JO - Scandinavian Journal of Haematology

JF - Scandinavian Journal of Haematology

IS - 3

ER -

The Effect of Vincristine on Haemoglobin Synthesis

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this