The effect of trihexphenidyl (artane) on memory in schizophrenic patients

Shmuel Fennig*, Yosi Levine, Silvana Naisberg, Avner Elizur

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Shmuel Fennig, Yosi Levine, Silvana Naisberg and Avner Elizur: The Effect of Trihexphenidyl (Artane) on Memory in Schizophrenic Patients. Prog. Neuro-Psychopharmacol. and Biol. Psychiat. 1987, 11: 71-78. 1. 1. The anticholinergic effect of trihexphenidyl on memory function of 20 schizophrenic patients has been investigated in a double blind cross-over design. 2. 2. Impairment of immediate memory and short term memory was evident after trihexphenidyl treatment in comparison with placebo. Sensory short term memory tested by visual tasks and remote memory showed no significant statistical differences. 3. 3. Our data suggested that trihexphenidyl due to its anticholinergic effect might impair memory function.

Original languageEnglish
Pages (from-to)71-78
Number of pages8
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Issue number1
StatePublished - 1987


  • anticholinergic effect
  • memory function
  • trihexphenidyl


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