TY - JOUR
T1 - The effect of topical retenoic acid compared to dinitrofluorobenzene (DNF) on mouse corneal langerhans cells
AU - Yassur, Y.
AU - Kremer, I.
AU - Gaba, M.
AU - Abramovitz, A.
PY - 1997
Y1 - 1997
N2 - Purpose. To invest ig ate ;he effect of retinoic acid compared to DNFB on mouse corneal Langerhans eelIs (LC). Method. Isot retino in and -st ret in ate (0. 2%} dissolved in yellow vaseline were applied twice daily to the mouse cornea for 10 days, Their long-term effect on the mouse corneal LC was compared wLth the effect of a single applicat ion of DNFB to the corneal surface of mice followed for 2,4,S and 21 days. Results. DNFB induced proliferation and migrâti an of corneal LC. In contrast, both ret inoids caused red act ion in peripheral corneal LC without migration towards corneal center, However, reduct ion in per ipheral corneal LC was also found following application of ehe ret inoid solvent. Conelusion s. Retinoids d ? not induce proliferat ion and centripetal migration of peripheral corneal LC as does DNTB. As both retinoids and their solvent caused reduction in corneal LC, it is suggested that this reducti on is an artifact if tissue preparation.
AB - Purpose. To invest ig ate ;he effect of retinoic acid compared to DNFB on mouse corneal Langerhans eelIs (LC). Method. Isot retino in and -st ret in ate (0. 2%} dissolved in yellow vaseline were applied twice daily to the mouse cornea for 10 days, Their long-term effect on the mouse corneal LC was compared wLth the effect of a single applicat ion of DNFB to the corneal surface of mice followed for 2,4,S and 21 days. Results. DNFB induced proliferation and migrâti an of corneal LC. In contrast, both ret inoids caused red act ion in peripheral corneal LC without migration towards corneal center, However, reduct ion in per ipheral corneal LC was also found following application of ehe ret inoid solvent. Conelusion s. Retinoids d ? not induce proliferat ion and centripetal migration of peripheral corneal LC as does DNTB. As both retinoids and their solvent caused reduction in corneal LC, it is suggested that this reducti on is an artifact if tissue preparation.
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AN - SCOPUS:33749212308
SN - 0146-0404
VL - 38
SP - S517
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
IS - 4
ER -