The effect of topical ceftazidime on pseudomonas keratitis in rabbits

I. Kremer; A. Robinson; M. Braffman; M. Drucker; M. Goldenfeld; Z. Samra; N. Myszne-Daye; D. Gaton; H. Savir

doi:10.1097/00003226-199407000-00013

The effect of topical ceftazidime on pseudomonas keratitis in rabbits

I. Kremer^*, A. Robinson, M. Braffman, M. Drucker, M. Goldenfeld, Z. Samra, N. Myszne-Daye, D. Gaton, H. Savir

^*Corresponding author for this work

Rabin Medical Center Israel

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Ceftazidime is a β-lactam antibiotic highly effective against Pseudomonas aeruginosa infection. Using a rabbit model of Pseudomonas keratitis, 10³ bacteria (in 20 μl) were injected unilaterally into the corneal stroma of albino rabbits. Twenty-six hours after inoculation, topical Ceftazidime (50 mg/ml) drops were administered for 48 h, following which the corneal tissue was cultured. Eighteen of 20 corneal cultures (90%) from rabbits treated with Ceftazidime drops were negative. In comparison, all untreated control group cultures showed florid bacterial growth. These results suggest that topical Ceftazidime may be a useful agent in the treatment of P. aeruginosa keratitis.

Original language	English
Pages (from-to)	360-363
Number of pages	4
Journal	Cornea
Volume	13
Issue number	4
DOIs	https://doi.org/10.1097/00003226-199407000-00013
State	Published - 1994
Externally published	Yes

Keywords

Ceftazidime
Pseudomonas keratitis

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10.1097/00003226-199407000-00013

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title = "The effect of topical ceftazidime on pseudomonas keratitis in rabbits",

abstract = "Ceftazidime is a β-lactam antibiotic highly effective against Pseudomonas aeruginosa infection. Using a rabbit model of Pseudomonas keratitis, 103 bacteria (in 20 μl) were injected unilaterally into the corneal stroma of albino rabbits. Twenty-six hours after inoculation, topical Ceftazidime (50 mg/ml) drops were administered for 48 h, following which the corneal tissue was cultured. Eighteen of 20 corneal cultures (90%) from rabbits treated with Ceftazidime drops were negative. In comparison, all untreated control group cultures showed florid bacterial growth. These results suggest that topical Ceftazidime may be a useful agent in the treatment of P. aeruginosa keratitis.",

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AU - Kremer, I.

AU - Robinson, A.

AU - Braffman, M.

AU - Drucker, M.

AU - Goldenfeld, M.

AU - Samra, Z.

AU - Myszne-Daye, N.

AU - Gaton, D.

AU - Savir, H.

PY - 1994

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AB - Ceftazidime is a β-lactam antibiotic highly effective against Pseudomonas aeruginosa infection. Using a rabbit model of Pseudomonas keratitis, 103 bacteria (in 20 μl) were injected unilaterally into the corneal stroma of albino rabbits. Twenty-six hours after inoculation, topical Ceftazidime (50 mg/ml) drops were administered for 48 h, following which the corneal tissue was cultured. Eighteen of 20 corneal cultures (90%) from rabbits treated with Ceftazidime drops were negative. In comparison, all untreated control group cultures showed florid bacterial growth. These results suggest that topical Ceftazidime may be a useful agent in the treatment of P. aeruginosa keratitis.

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The effect of topical ceftazidime on pseudomonas keratitis in rabbits

Abstract

Keywords

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