The effect of tetracycline administration on iron absorption in mice

M. Djaldetti, P. Fishman, I. Notti, H. Bessler

Research output: Contribution to journalArticlepeer-review


The effect of perorally administered tetracycline, chloramphenicol and streptomycin, antibiotics known as inhibitors of protein synthesis, on the iron absorption in mice was examined. Tetracycline caused a marked decrease in iron absorption observed shortly after its administration. On the other hand, both chloramphenicol and streptomycin caused a marked increase in iron absorption. There was no difference between results when bivalent or trivalent iron was given. The possible mechanisms for the explanation of the effect of these antibiotics on iron transfer through the small intestine mucosa are discussed.

Original languageEnglish
Pages (from-to)150-152
Number of pages3
JournalBiomedicine Express
Issue number5
StatePublished - 1981
Externally publishedYes


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