TY - JOUR
T1 - The effect of surgical castration on lipid metabolism in premenopausal and postmenopausal women
AU - Goldman, G. A.
AU - Schoenfeld, A.
AU - Royburt, M.
AU - Zeldin, L.
AU - Kaplan, B.
AU - Ovadia, J.
PY - 1996/6
Y1 - 1996/6
N2 - Objective: To investigate the effect of endogenous estrogen on lipid and lipoprotein metabolism in premenopausal and postmenopausal women. Design: Prospective randomized study. Setting: Department of Obstetrics-Gynecology, Beilinson Medical Center and Tel-Aviv University Medical School, Israel. Subjects: Twenty-seven women, 15 premenopausal and 12 postmenopausal, undergoing surgical castration (total abdominal hysterectomy and bilateral salpingo;oophorectomy). Method: Blood samples were drawn before the surgical intervention and after a 6-month interval. Main outcome measures: Assays were performed for estradiol, luteinising hormone and follicle-stimulating hormone, and triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol and total cholesterol/HDL as well as HDL/LDL ratio. Results: No significant differences were found in both groups, before castration and after 6 months. A modest, but statistically significant, rise in triglycerides was observed in the premenopausal group. Conclusions: The serum lipid and lipoprotein profile encountered in premenopausal and postmenopausal women were unchanged 6 months after surgical castration. The clinical significance indicates that the effect of endogenous estrogen on lipid metabolism is doubtful and should be further investigated.
AB - Objective: To investigate the effect of endogenous estrogen on lipid and lipoprotein metabolism in premenopausal and postmenopausal women. Design: Prospective randomized study. Setting: Department of Obstetrics-Gynecology, Beilinson Medical Center and Tel-Aviv University Medical School, Israel. Subjects: Twenty-seven women, 15 premenopausal and 12 postmenopausal, undergoing surgical castration (total abdominal hysterectomy and bilateral salpingo;oophorectomy). Method: Blood samples were drawn before the surgical intervention and after a 6-month interval. Main outcome measures: Assays were performed for estradiol, luteinising hormone and follicle-stimulating hormone, and triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol and total cholesterol/HDL as well as HDL/LDL ratio. Results: No significant differences were found in both groups, before castration and after 6 months. A modest, but statistically significant, rise in triglycerides was observed in the premenopausal group. Conclusions: The serum lipid and lipoprotein profile encountered in premenopausal and postmenopausal women were unchanged 6 months after surgical castration. The clinical significance indicates that the effect of endogenous estrogen on lipid metabolism is doubtful and should be further investigated.
KW - Estrogen
KW - Lipoproteins
KW - Post-hysterectomy
UR - http://www.scopus.com/inward/record.url?scp=0030011920&partnerID=8YFLogxK
U2 - 10.1016/0301-2115(96)02391-3
DO - 10.1016/0301-2115(96)02391-3
M3 - מאמר
AN - SCOPUS:0030011920
VL - 66
SP - 133
EP - 136
JO - European Journal of Obstetrics, Gynecology and Reproductive Biology
JF - European Journal of Obstetrics, Gynecology and Reproductive Biology
SN - 0028-2243
IS - 2
ER -