The effect of sildenafil on ocular blood flow

A. Harris; L. Kagemann; R. Ehrlich; Y. Ehrlich; C. R. López; V. A. Purvin

doi:10.1136/bjo.2007.131789

The effect of sildenafil on ocular blood flow

A. Harris^*, L. Kagemann, R. Ehrlich, Y. Ehrlich, C. R. López, V. A. Purvin

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

60 Scopus citations

Abstract

Sildenafil is a potent phosphodiesterase (PDE) 5 inhibitor that is used for patients with erectile dysfunction. Sildenafil induces vasodilation in selected smooth muscle via increased levels of guanosine 3′, 5′ cyclic monophosphate and increase in nitric oxide. The vasodilatory effects of the PDE 5 inhibitors led us to review its effect on the ocular vasculature. Sildenafil appears to increase blood flow velocity significantly in the retrobulbar and choroidal circulation. Most studies suggest an increase in choroidal blood flow, with a lesser effect on the retinal vasculature.

Original language	English
Pages (from-to)	469-473
Number of pages	5
Journal	British Journal of Ophthalmology
Volume	92
Issue number	4
DOIs	https://doi.org/10.1136/bjo.2007.131789
State	Published - Apr 2008
Externally published	Yes

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AU - López, C. R.

AU - Purvin, V. A.

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The effect of sildenafil on ocular blood flow

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