The effect of restraint stress on the normal colon and on intestinal inflammation in a model of experimental colitis

Eran Israeli*, Tiberiu Hershcovici, Eduard Berenshtein, Giulliana Zannineli, Dov Wengrower, Ofra Weiss, Mordechai Chevion, Eran Goldin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Stress may induce development of inflammation in animal models of colitis. The effects of restraint stress on oxidative damage and on antioxidants in the normal colonic mucosa were studied. The effect of stress on the severity of indicators of inflammation, as well as the importance of mucosal substance P (SP) as a mediator of this effect were investigated in the TNBS-colitis model. Restraint stress significantly increased malondialdehyde levels and reduced levels of low-molecular-weight-antioxidants in the normal colon. ATP and the mucosal "energy charge" decreased substantially with chronic stress. Chronic stress worsened the extent of inflammation in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Mucosal SP content was not affected by exposure to chronic stress but increased after induction of colitis. The increase was greater when colitis was induced after exposure to stress. We conclude that chronic restraint stress causes oxidative damage to the normal colon and aggravates intestinal inflammation induced by TNBS. This effect may be mediated by SP.

Original languageEnglish
Pages (from-to)88-94
Number of pages7
JournalDigestive Diseases and Sciences
Volume53
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

Keywords

  • Colonic mucosa
  • Oxidation
  • Restraint stress
  • Substance P
  • TNBS-colitis

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