The effect of repeated doses of 30 mg pyridostigmine bromide on pilot performance in an A-4 flight simulator

S. Izraeli, D. Avgar, S. Almog, I. Shochat, Z. Tochner, A. Tamir, J. Ribak

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of repeated doses of 30 mg pyridostigmine bromide every 8 h on flight skills in an A-4 simulator was tested in this crossover double-blind placebo-controlled study on 10 pilots experienced in actual and simulated A-4 flights. The pilots flew two test simulator flights 2 h after the fourth dose of pyridostigmine or placebo. The flights profile included navigation, rapid ascent, 360° turns, and instrument landing. Each flight lasted approximately 20 min. Flight parameters measured included indicated air speed, true heading, barometric altitude, vertical velocity, and bank. The mean whole blood cholinesterase inhibition level was 29%. There was no decrement in performance under treatment with pyridostigmine in the percent of deviation time from the prescribed limits or in the average duration or magnitude of the deviation in each of the flight parameters. We conclude that pyriodostigmine bromide in repeated doses of 30 mg every 8 h does not appear to influence pilot performance during short A-4 missions.

Original languageEnglish
Pages (from-to)430-432
Number of pages3
JournalAviation Space and Environmental Medicine
Volume61
Issue number5
StatePublished - 1990
Externally publishedYes

Fingerprint

Dive into the research topics of 'The effect of repeated doses of 30 mg pyridostigmine bromide on pilot performance in an A-4 flight simulator'. Together they form a unique fingerprint.

Cite this