The effect of repeated amphetamine treatment on striatal DA transporter and rotation in rats

Matti Mintz; Irit Gordon; Netta Roz; Moshe Rehavi

doi:10.1016/0006-8993(94)90529-0

The effect of repeated amphetamine treatment on striatal DA transporter and rotation in rats

Matti Mintz^*
, Irit Gordon
, Netta Roz
, Moshe Rehavi

^*Corresponding author for this work

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The effect of repeated amphetamine treatment on the involvement of the striatal DA transporters in rotation was tested in rats. Repeated amphetamine treatment had no effect on [³H]DA uptake or [³H]GBR-12935 binding density. However, unlike the naive rats who rotated away from the striatum with a lower density of DA transporters, rats sensitized to amphetamine rotated toward the striatum with a lower density of DA transporters. These findings imply that repeated amphetamine augments the subcortical involvement in behavioral output.

Original language	English
Pages (from-to)	239-242
Number of pages	4
Journal	Brain Research
Volume	668
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(94)90529-0
State	Published - 30 Dec 1994

Keywords

DA
DA transporter
DA uptake
Repeated amphetamine
Rotation
Sensitization
Striatum

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10.1016/0006-8993(94)90529-0

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abstract = "The effect of repeated amphetamine treatment on the involvement of the striatal DA transporters in rotation was tested in rats. Repeated amphetamine treatment had no effect on [3H]DA uptake or [3H]GBR-12935 binding density. However, unlike the naive rats who rotated away from the striatum with a lower density of DA transporters, rats sensitized to amphetamine rotated toward the striatum with a lower density of DA transporters. These findings imply that repeated amphetamine augments the subcortical involvement in behavioral output.",

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AU - Rehavi, Moshe

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Y1 - 1994/12/30

N2 - The effect of repeated amphetamine treatment on the involvement of the striatal DA transporters in rotation was tested in rats. Repeated amphetamine treatment had no effect on [3H]DA uptake or [3H]GBR-12935 binding density. However, unlike the naive rats who rotated away from the striatum with a lower density of DA transporters, rats sensitized to amphetamine rotated toward the striatum with a lower density of DA transporters. These findings imply that repeated amphetamine augments the subcortical involvement in behavioral output.

AB - The effect of repeated amphetamine treatment on the involvement of the striatal DA transporters in rotation was tested in rats. Repeated amphetamine treatment had no effect on [3H]DA uptake or [3H]GBR-12935 binding density. However, unlike the naive rats who rotated away from the striatum with a lower density of DA transporters, rats sensitized to amphetamine rotated toward the striatum with a lower density of DA transporters. These findings imply that repeated amphetamine augments the subcortical involvement in behavioral output.

KW - DA

KW - DA transporter

KW - DA uptake

KW - Repeated amphetamine

KW - Rotation

KW - Sensitization

KW - Striatum

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The effect of repeated amphetamine treatment on striatal DA transporter and rotation in rats

Abstract

Keywords

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